{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:28:00Z","timestamp":1761017280892},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We retrospectively analysed the clinical characteristics, electroencephalogram (EEG) records, brain magnetic resonance imaging (MRI) scans, antiepileptic therapy and prognosis of a case series with ambulatory non\u2010convulsive status epilepticus (NCSE) which evolved into a malignant form (mNCSE). mNCSE was defined as NCSE that continues or recurs five days or more after the onset of general anaesthesia, including those cases where NCSE recurs upon reduction or withdrawal of anaesthetic therapy. Four women and two men were studied. The mean age was 42.8 years (range: 19\u201063 years). Two of six patients had a previous diagnosis of epilepsy. Four patients died. Two patients had a good outcome with return to consciousness and activities of daily life, and one of these subjects developed temporal lobe epilepsy. In four patients, the cause of mNCSE was encephalitis. Clinical presentation was complex partial status epilepticus (CPSE) in three patients and generalised NCSE (GNCSE) in the other three. Two of the latter had encephalitis and one was diagnosed with progressive myoclonus epilepsy (PME) of Lafora type. The mean duration of the NCSE episode was 47.5 days (range: 9\u2010139 days; SD: 53.1). In three patients, continuous or rhythmic focal epileptiform discharges were the EEG pattern at onset. In the other three, continuous rhythmic generalised spike\u2010wave, polyspike\u2010wave or sharp slow\u2010wave complexes were observed. Antiepileptic treatment was heterogeneous and patients were treated with an average of 6.0 AEDs (range: 3\u201010; SD: 3.0). In summary, mNCSE is a severe epileptic condition that occurs often in the context of encephalitis or pre\u2010existing epilepsy. Both CPSE and GNCSE may occur. Although high mortality is associated with mNCSE, some patients may survive with normal or good recovery.<\/jats:p>","DOI":"10.1684\/epd.2012.0488","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:19Z","timestamp":1564752259000},"page":"41-50","source":"Crossref","is-referenced-by-count":12,"title":["Ambulatory non\u2010convulsive status epilepticus evolving into a malignant form"],"prefix":"10.1002","volume":"14","author":[{"given":"Jos\u00e9 L","family":"Fern\u00e1ndez\u2010Torre","sequence":"first","affiliation":[{"name":"Department of Clinical Neurophysiology \u201cMarqu\u00e9s de Valdecilla\u201d University Hospital Santander Cantabria Spain"},{"name":"Department of Physiology and Pharmacology University of Cantabria Santander Cantabria Spain"},{"name":"Instituto de Formaci\u00f3n e Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IFIMAV) Santander"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter W","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine Johns Hopkins Bayview Medical Center Baltimore USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano","family":"Rebollo","sequence":"additional","affiliation":[{"name":"Department of Neurology \u201cMarqu\u00e9s de Valdecilla\u201d University Hospital Santander Cantabria Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agust\u00edn","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of Radiology \u201cMarqu\u00e9s de Valdecilla\u201d University Hospital Santander Cantabria Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A","family":"Hern\u00e1ndez\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto de Formaci\u00f3n e Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IFIMAV) Santander"},{"name":"Department of Intensive 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