{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:36:01Z","timestamp":1768293361791,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>An open pilot study to evaluate the effect of pregabalin (PGB) as add\u2010on therapy on seizure control, quality of life, and anxiety in patients with brain tumour\u2010related epilepsy (BTRE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We recruited 25 consecutive patients with BTRE and uncontrolled seizures. At baseline and during follow\u2010up, patients underwent a complete physical and neurological examination and were evaluated using the QOLIE 31P (V2), EORTC QLQ C30, Adverse Events Profile, and Hamilton Anxiety Rating Scale (HAM\u2010A). At baseline, a seizure diary was given.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During follow\u2010up, 17 patients underwent chemotherapy, none underwent radiotherapy, 9 had disease progression, and 3 died. Mean duration of follow\u2010up was 4.1 months. Mean PGB dosage was 279 mg\/day. At baseline, mean weekly seizure frequency was 5.3 (\u00b110) and at last available follow\u2010up visit was 2.8\u00b15. This difference was statistically significant (<jats:italic>p<\/jats:italic>=0.016). The responder rate was 76%. Ten patients dropped out; 4 as a result of seizure worsening, 1 as a result of unchanged seizure frequency, 3 as a result of a lack of compliance, and 2 as a result of side effects. Based on the QOLIE\u201031\u2010P, a significant improvement of the subscale \u201cseizure worry\u201d (<jats:italic>p<\/jats:italic>=0.004) and a significant decrease in distress scores related to AEDs and social life (<jats:italic>p<\/jats:italic>=0.009 and <jats:italic>p<\/jats:italic>=0.008, respectively) were observed. A significant decrease in HAMA score (<jats:italic>p<\/jats:italic>=0.002) was documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data indicate that PGB may represent a valid alternative as add\u2010on treatment in this patient population, based on its efficacy on seizure control and anxiety.<\/jats:p><\/jats:sec>","DOI":"10.1684\/epd.2012.0542","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:19Z","timestamp":1564752259000},"page":"388-397","source":"Crossref","is-referenced-by-count":27,"title":["Effect of pregabalin add\u2010on treatment on seizure control, quality of life, and anxiety in patients with brain tumour\u2010related epilepsy: a pilot study"],"prefix":"10.1002","volume":"14","author":[{"given":"Marta","family":"Maschio","sequence":"first","affiliation":[{"name":"Center for Tumor\u2010related Epilepsy UOSD Psychiatry, Health Direction National Institute for Cancer \u201cRegina Elena\u201d 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