{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T17:52:10Z","timestamp":1785606730427,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Juvenile myoclonic epilepsy (JME) is a frequent idiopathic generalised epilepsy syndrome with typical clinical and EEG features that can usually be controlled by valproate monotherapy. JME may be under\u2010diagnosed or misdiagnosed; in the latter case, it may be mistaken for partial epilepsy. The incorrect diagnosis of JME is likely to result in inappropriate therapy, which may, in turn, worsen the seizures. While a number of studies have documented that carbamazepine aggravates idiopathic generalised epilepsy, few have shown a worsening of symptoms following the administration of oxcarbazepine (OXC). We report the case of a 44\u2010year\u2010old male affected by JME in which the inappropriate use of OXC precipitated a dramatic worsening of myoclonic seizures. In this case, video\u2010EEG monitoring documented myoclonic status epilepticus with positive and negative myoclonus, correlating with repetitive, continuous, rhythmic, generalised polyspike\u2010and\u2010wave discharges. This is the first case of myoclonic status epilepticus induced by OXC in a patient with JME which is clearly documented by video\u2010EEG. A review of the literature with regards to OXC\u2010induced worsening of seizures is also presented. [<jats:italic>Published with video sequences<\/jats:italic>]<\/jats:p>","DOI":"10.1684\/epd.2013.0563","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:44Z","timestamp":1564752284000},"page":"181-187","source":"Crossref","is-referenced-by-count":19,"title":["Oxcarbazepine\u2010induced myoclonic status epilepticus in juvenile myoclonic epilepsy"],"prefix":"10.1002","volume":"15","author":[{"given":"Martina","family":"Fanella","sequence":"first","affiliation":[{"name":"Department of Neurology and Psychiatry Epilepsy Unit Sapienza University of Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Egeo","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry Epilepsy Unit Sapienza University of Rome"},{"name":"San Raffaele Pisana IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinane","family":"Fattouch","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry Epilepsy Unit Sapienza University of Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Casciato","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry Epilepsy Unit Sapienza University of Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Lapenta","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry Epilepsy Unit Sapienza University of Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Morano","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry Epilepsy Unit Sapienza University of Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Teresa","family":"Giallonardo","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry Epilepsy Unit Sapienza University of Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Di Bonaventura","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry Epilepsy Unit Sapienza University of Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000085872.37496.3F"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.19704.x"},{"key":"e_1_2_5_4_1","first-page":"253","volume-title":"Idiopathic generalized epilepsies","author":"Genton P","year":"1994"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.8.1106"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01464.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2009.01270.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2005.10.007"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.104968"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.76867"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00258.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1998.tb01268.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2006.12.001"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl047"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2012.0491"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01210.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01759.x"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2013.0563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:18:39Z","timestamp":1710778719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2013.0563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1684\/epd.2013.0563"],"URL":"https:\/\/doi.org\/10.1684\/epd.2013.0563","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}