{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:33:51Z","timestamp":1761514431098},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The aim of this observational study was to obtain information regarding efficacy and safety of add\u2010on levetiracetam (LEV; <jats:italic>n<\/jats:italic>=32) in Japanese patients with refractory partial seizures in an everyday clinical setting, relative to control AEDs (<jats:italic>n<\/jats:italic>=30). This is the first study of LEV add\u2010on therapy conducted in Japan since approval was made. The medical charts of patients were retrospectively reviewed. The efficacy variables were seizure freedom and \u226550% reduction in seizure frequency. A significantly higher response to LEV was demonstrated in patients with all seizure types at base\u2010line, relative to control AEDs. In patients with a duration of epilepsy of at least 10 years, significant effects in response to LEV were demonstrated with regards to efficacy variables, relative to control AEDs, thus providing meaningful results. Only two patients (6.2%) discontinued LEV treatment due to worsening of seizures, but no discontinuation was reported due to adverse events. LEV as add\u2010on therapy to other AEDs is a promising useful treatment option for patients with refractory partial seizures without notable effects on safety, indicating that this treatment regimen might be recommended for such patients.<\/jats:p>","DOI":"10.1684\/epd.2013.0576","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:44Z","timestamp":1564752284000},"page":"132-141","source":"Crossref","is-referenced-by-count":5,"title":["Levetiracetam add\u2010on therapy in Japanese patients with refractory partial epilepsy"],"prefix":"10.1002","volume":"15","author":[{"given":"Shigeya","family":"Tanaka","sequence":"first","affiliation":[{"name":"Tanaka Neurosurgical Clinic Kagoshima"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Asahikawa Medical College Hokkaido"},{"name":"Yamabiko Medical Welfare Center Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2005.09.003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1059-1311(02)00292-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2007.0137"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb04605.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(02)00247-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2009.06.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.11.1445"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(01)00323-0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181fd6170"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.2.236"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02496.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03047.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.19400.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3458.2007.00005.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2003.07.008"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2005.31504.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.04005.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000217916.00225.3a"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2007.02.011"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/seiz.2001.0605"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200002033420503"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2010.03.016"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308208101"},{"key":"e_1_2_6_25_1","first-page":"489","article-title":"Levetiracetam: a review of its use in epilepsy","volume":"71","author":"Lyseng\u2010Williamson KA","year":"2011","journal-title":"Drugs"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01866.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(03)00080-9"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/seiz.2000.0407"},{"key":"e_1_2_6_29_1","unstructured":"MurasakiM YagiK YamauchiT et al.Multicentre double\u2010blind randomised placebo\u2010controlled parallel\u2010group study of add\u2010on levetiracetam in Japanese patients with uncontrolled partial seizures. 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