{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:00:01Z","timestamp":1782997201528,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare intravenous valproate (IV\u2010VPA) with intravenous phenobarbitone (IV\u2010PB) in the treatment of established generalised convulsive status epilepticus (GCSE). Efficacy and safety were estimated using a common\u2010reference based indirect comparison meta\u2010analysis (CRBMA) methodology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomised controlled trials (RCTs) investigating the use of IV\u2010VPA or IV\u2010PB <jats:italic>versus<\/jats:italic> intravenous phenytoin (IV\u2010PHT) for GCSE were identified by a systematic search of the literature. A random effects model was used to estimate Mantel\u2010Haenszel odds ratios (ORs) for efficacy and safety of IV\u2010VPA or IV\u2010PB <jats:italic>versus<\/jats:italic> IV\u2010PHT in a standard meta\u2010analysis. Adjusted indirect comparisons were then made between VPA and PB using the obtained results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CRBMA showed that VPA does not lead to significantly higher seizure cessation (OR 1.00; 95% CI: 0.36\u20102.76) compared to PB, although it exhibits fewer adverse effects (OR 0.17; 95% CI: 0.04\u20100.71). Results of this CRBMA are consistent with results of a recently published head\u2010to\u2010head comparison of IV\u2010VPA and IV\u2010PB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is insufficient evidence to demonstrate superiority of IV\u2010VPA over IV\u2010PB for the treatment of GCSE in terms of efficacy. Some direct and indirect comparisons suggest that VPA has a better safety profile than PB. However, the limited numbers of underpowered RCTs included in this meta\u2010analysis are not sufficient to justify a change in clinical practice. More rigorous and appropriately powered RCTs are therefore required to definitively determine the efficacy and tolerability of VPA for the treatment of GCSE.<\/jats:p><\/jats:sec>","DOI":"10.1684\/epd.2013.0601","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:44Z","timestamp":1564752284000},"page":"314-323","source":"Crossref","is-referenced-by-count":21,"title":["A common reference\u2010based indirect comparison meta\u2010analysis of intravenous valproate <i>versus<\/i> intravenous phenobarbitone for convulsive status epilepticus"],"prefix":"10.1002","volume":"15","author":[{"given":"Francesco","family":"Brigo","sequence":"first","affiliation":[{"name":"Department of Neurological and Movement Sciences. 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