{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:24:11Z","timestamp":1787163851110,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Aim.<\/jats:italic>\n                    We retrospectively analysed the electroclinical features, treatment, and outcome in patients with unilateral polymicrogyria (PMG), focussing on epileptic syndrome with or without encephalopathy, with status epilepticus during sleep (ESES) or continuous spikes and waves during slow sleep (CSWS) syndrome.\n                    <jats:italic>Methods.<\/jats:italic>\n                    From June 1990 to December 2012, 39 males and 27 females, aged 5\u201026 years, were studied. We did not include patients with bilateral PMG or cases with unilateral PMG associated with other cerebral lesions. The mean follow\u2010up period was 12 years (range: 3\u201022 years).\n                    <jats:italic>Results.<\/jats:italic>\n                    Mean age at epilepsy onset was 6.5 years. Focal motor seizures occurred in all cases and 25 had secondary generalised seizures. Six patients also had complex focal seizures. Interictal EEG recordings showed focal spikes in all cases. For 43 of 53 patients with epilepsy, aged 2\u20109.5 years, the electroclinical features changed. An increase in frequency of focal motor seizures was reported in 20 patients, negative myoclonus occurred in 32 patients, atypical absences in 25 patients, and positive myoclonus in 19 patients. All patients had a continuous symmetric or asymmetric pattern of spike\u2010wave activity during slow\u2010wave sleep.\n                    <jats:italic>Conclusion.<\/jats:italic>\n                    For patients presenting with congenital hemiparesis, negative or positive myoclonus, and absences and focal motor seizures with ESES\/CSWS, unilateral PMG should be considered. Brain MRI is mandatory to confirm this cortical malformation. The most commonly used treatments were clobazam, ethosuximide, and sulthiame, alone or in combination. For refractory cases, high\u2010dose steroids were administered and surgery was performed in two patients. Outcome was relatively benign.\n                  <\/jats:p>","DOI":"10.1684\/epd.2013.0612","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T09:24:44Z","timestamp":1564737884000},"page":"417-427","source":"Crossref","is-referenced-by-count":28,"title":["Congenital hemiparesis, unilateral polymicrogyria and epilepsy with or without status epilepticus during sleep: a study of 66 patients with long\u2010term follow\u2010up"],"prefix":"10.1002","volume":"15","author":[{"given":"Roberto Horacio","family":"Caraballo","sequence":"first","affiliation":[{"name":"Department of Neurology Hospital Nacional de Pediatr\u00eda Juan P Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Oscar","family":"Cers\u00f3simo","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Nacional de Pediatr\u00eda Juan P Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Sebasti\u00e1n","family":"Fortini","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Nacional de Pediatr\u00eda Juan P Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Ornella","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Nacional de Pediatr\u00eda Juan P Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Celeste","family":"Buompadre","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Nacional de Pediatr\u00eda Juan P Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Vilte","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Nacional de Pediatr\u00eda Juan P Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Princich","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Nacional de Pediatr\u00eda Juan P Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalio","family":"Fejerman","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Nacional de Pediatr\u00eda Juan P Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"130","volume-title":"Epilepsy in children","author":"Aicardi 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