{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:09:40Z","timestamp":1762459780560},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Early\u2010onset absence epilepsy refers to patients with absence seizures beginning before age 4 and comprises a heterogeneous group of epilepsies. Onset of absence seizures in the first year of life is very rare. We report a boy with absence seizures with onset at age 11 months, whose seizures increased in frequency after the introduction of valproic acid (VPA) treatment and substantially improved upon cessation of treatment. The mechanism of seizure worsening did not involve VPA toxicity, encephalopathy, Glut\u20101 deficiency or overdosage, and the reason for absence seizure aggravation remained unclear. The patient showed complete control of absence seizures with levetiracetam treatment and the course was benign, both in terms of seizure control and neuropsychological aspects. The similar overall electroclinical picture and outcome between children with early\u2010onset absences and those with CAE support the view that these conditions are a continuum within the wide spectrum of IGE. [<jats:italic>Published with video sequences<\/jats:italic>]<\/jats:p>","DOI":"10.1684\/epd.2013.0616","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:44Z","timestamp":1564752284000},"page":"440-443","source":"Crossref","is-referenced-by-count":9,"title":["Early\u2010onset absence epilepsy aggravated by valproic acid: a video\u2010EEG report"],"prefix":"10.1002","volume":"15","author":[{"given":"Vincenzo","family":"Belcastro","sequence":"first","affiliation":[{"name":"Neurology Unit Department of Neuroscience Sant'Anna Hospital Como Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Horacio","family":"Caraballo","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Nacional de Pediatria \u201cProf Dr Juan P Garrahan\u201d Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Romeo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Fatebenefratelli e Oftalmico Hospital Milan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Striano","sequence":"additional","affiliation":[{"name":"Pediatric Neurology and Muscular Diseases Unit Department of Neurosciences, Rehabilitation, Ophtalmology, Genetics Maternal and Child Health University of Genoa \u201cG Gaslini\u201d Institute Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03871.x"},{"key":"e_1_2_5_3_1","first-page":"284","volume-title":"Absences and related epileptic syndromes","author":"Aicardi J","year":"1995"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2006.08.011"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02926.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00874.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01956423"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00361231"},{"key":"e_1_2_5_9_1","first-page":"77","volume-title":"Epileptic syndromes in infancy, childhood and adolescence","author":"Dravet C","year":"2005"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(99)00113-8"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.042007941.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2011.06.008"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.00314.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01777.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.12.90"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70043-7"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318247ff54"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21724"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl047"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20555"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2013.0616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:19:33Z","timestamp":1710778773000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2013.0616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1684\/epd.2013.0616"],"URL":"https:\/\/doi.org\/10.1684\/epd.2013.0616","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}