{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:42:02Z","timestamp":1780422122018,"version":"3.54.1"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T00:00:00Z","timestamp":1403049600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>New antiepileptic drug (AED) options for generalised seizure types have been adopted for use as treatment for Unverricht\u2010Lundborg disease. Whether this has led to improved seizure control or functional outcome in ULD patients remains obscure. We retrospectively identified all patients seen at Helsinki University Hospital due to Unverricht\u2010Lundborg disease during 2003\u20132008 in order to determine which AED treatments had been retained for long\u2010term use. The majority of the patients had severe functional disabilities. In the year preceding the last hospital visit, all patients (<jats:italic>n<\/jats:italic>=20) were receiving polytherapy and 14 patients had been free of tonic\u2010clonic seizures. During follow\u2010up, improvement in myoclonia had been recorded for the majority of patients with either add\u2010on piracetam, topiramate, or levetiracetam, but valproate was still in use by all patients. Treatment with lamotrigine had been started and retained less often relative to other AEDs. Add\u2010on AED treatment was often associated with significant adverse effects. Unverricht\u2010Lundborg disease patients may benefit from add\u2010on treatment with levetiracetam or topiramate for seizure control. Treatment of eventual comorbidities with other than AEDs is also discussed.<\/jats:p>","DOI":"10.1684\/epd.2014.0654","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:44Z","timestamp":1564752284000},"page":"191-195","source":"Crossref","is-referenced-by-count":8,"title":["Seizure control in Unverricht\u2010Lundborg disease: a single\u2010centre study"],"prefix":"10.1002","volume":"16","author":[{"given":"Reina","family":"Roivainen","sequence":"first","affiliation":[{"name":"Department of Neurology Helsinki University Central Hospital  Helsinki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti K.","family":"Karvonen","sequence":"additional","affiliation":[{"name":"Department of Neurology Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarja","family":"Puumala","sequence":"additional","affiliation":[{"name":"Department of Neurology Helsinki University Central Hospital  Helsinki"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2004.11.014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000110193.78872.DD"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00829.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1982.00510160042008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01118.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.3.344"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(97)00069-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.56902.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00553.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2007.11.006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70043-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2008.0168"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2014.0654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:04:18Z","timestamp":1710777858000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2014.0654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1684\/epd.2014.0654"],"URL":"https:\/\/doi.org\/10.1684\/epd.2014.0654","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}