{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:01:03Z","timestamp":1778857263236,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T00:00:00Z","timestamp":1412726400000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Hearing loss has been reported with valproic acid (VPA) use. However, this is the first case of VPA\u2010induced hearing loss that was tested and confirmed with a VPA rechallenge, supported by serial audiometry and pharmacokinetic modelling. A 39\u2010year\u2010old truck driver with temporal lobe epilepsy was treated with VPA at 400 mg, twice daily, and developed hearing loss after each dose, but recovered within three hours. Hearing loss fully resolved after VPA discontinuation. Audiometry performed five hours after VPA rechallenge showed significant improvement in hearing thresholds. Pharmacokinetic modelling during the VPA rechallenge showed that hearing loss occurred at a level below the therapeutic range. Brainstem auditory evoked potential at three months after VPA discontinuation showed bilateral conduction defect between the cochlear and superior olivary nucleus, supporting a pre\u2010existing auditory deficit. VPA may cause temporary hearing threshold shift. Pre\u2010existing auditory defect may be a risk factor for VPA\u2010induced hearing loss. Caution should be taken while prescribing VPA to patients with pre\u2010existing auditory deficit.<\/jats:p>","DOI":"10.1684\/epd.2014.0671","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:44Z","timestamp":1564752284000},"page":"375-379","source":"Crossref","is-referenced-by-count":9,"title":["Valproate\u2010induced reversible sensorineural hearing loss: a case report with serial audiometry and pharmacokinetic modelling during a valproate rechallenge"],"prefix":"10.1002","volume":"16","author":[{"given":"Li\u2010Ling","family":"Yeap","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Malaya, Kuala Lumpur"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kheng\u2010Seang","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, University of Malaya, Kuala Lumpur"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoke\u2010Lin","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Malaya, Kuala Lumpur"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Zukiflee Abu","family":"Bakar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaringology, Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong\u2010Tin","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, University of Malaya, Kuala Lumpur"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.12.1896"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2003.00538.x"},{"key":"e_1_2_5_4_1","first-page":"139","article-title":"Comparative in vivo bioequivalence and in vitro dissolution of two valproic acid sustained\u2010release formulations","volume":"2","author":"Fujii A","year":"2009","journal-title":"Drug Des Devel Ther"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2005.01.005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.42.1153"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2006.12.011"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1358\/mf.2007.29.10.1116313"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.5414\/CPP48767"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2710.2002.00440.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199906000-00019"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2009.09.017"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270011428138"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1995.tb03295.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1997.tb04301.x"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2014.0671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:05:50Z","timestamp":1710777950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2014.0671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1684\/epd.2014.0671"],"URL":"https:\/\/doi.org\/10.1684\/epd.2014.0671","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9]]}}}