{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:54:06Z","timestamp":1780419246880,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"vor","delay-in-days":55,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Aim<\/jats:italic>\n                    . The aim of this meta\u2010analysis was to assess the relationship between tumour location and preoperative seizure incidence in patients with gliomas.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    . Systematic computerised searches of PubMed and the Web of Knowledge were performed. The meta\u2010analysis of pooled odds ratio (OR) and 95% confidence interval (CI) for preoperative seizure risk, stratified by tumour location, were calculated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    . Eleven studies with 2,047 patients were included for meta\u2010analysis. For gliomas with or without frontal lobe involvement, the preoperative seizure incidence ranged from 31.7% (19\/60) to 85.7% (156\/182) and 19.7% (12\/61) to 85.7% (12\/14), respectively; the pooled OR was 1.560 (95% CI: 1.266\u20131.923; Z: 4.17;\n                    <jats:italic>p<\/jats:italic>\n                    =0.000). For gliomas with or without temporal lobe involvement, seizure incidence was 22.6% (7\/31) to 91.7% (11\/12) and 26.7% (24\/90) to 78.7% (174\/221), respectively; the pooled OR was 1.070 (95% CI: 0.794\u20131.443; Z: 0.45;\n                    <jats:italic>p<\/jats:italic>\n                    =0.656). For gliomas with or without parietal lobe involvement, seizure incidence was 18.1% (3\/16) to 100.0% (3\/3) and 26.7% (28\/105) to 80.4% (226\/281), respectively; the pooled OR was 0.770 (95% CI: 0.570\u20131.040; Z: 1.71;\n                    <jats:italic>p<\/jats:italic>\n                    =0.088). For gliomas with or without occipital lobe involvement, seizure incidence was 0.0% (0\/2) to 100.0% (2\/2) and 26.8% (30\/112) to 75.7% (56\/74), respectively; the pooled OR was 0.336 (95% CI: 0.164\u20130.686; Z: 2.99;\n                    <jats:italic>p<\/jats:italic>\n                    =0.003). For gliomas with or without insula lobe involvement, seizure incidence was 34.8% (8\/23) to 72.0% (77\/107) and 34.3% (60\/175) to 81.3% (247\/304), respectively; the pooled OR was 1.058 (95% CI: 0.765\u20131.463; Z: 0.34;\n                    <jats:italic>p<\/jats:italic>\n                    =0.732). No significant publication bias was found.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Our meta\u2010analysis indicates that frontal lobe gliomas are related to a higher preoperative seizure incidence, while occipital lobe gliomas are related to a lower incidence.\n                  <\/jats:p>","DOI":"10.1684\/epd.2015.0788","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T09:24:29Z","timestamp":1564737869000},"page":"397-408","source":"Crossref","is-referenced-by-count":17,"title":["Relationship between tumour location and preoperative seizure incidence in patients with gliomas: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"17","author":[{"given":"Xing","family":"Su","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Second Affiliated Hospital of Soochow University Suzhou"},{"name":"Department of Neurosurgery Affiliated Hospital of Nantong University Nantong City Jiangsu Province"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Nantong University Nantong city Jiangsu province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong\u2010Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Second Affiliated Hospital of Soochow University Suzhou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Second Affiliated Hospital of Soochow University 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