{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:32:37Z","timestamp":1766158357265},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T00:00:00Z","timestamp":1467158400000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this case\u2010matched study was to determine how frequently fibromyalgia is associated with different paroxysmal neurological disorders and explore the utility of fibromyalgia as a predictor for the diagnosis of psychogenic non\u2010epileptic seizures. The billing diagnosis codes of 1,730 new, non\u2010selected patient encounters were reviewed over a three\u2010year period for an epileptologist in a neurology clinic to identify all patients with historical diagnoses of fibromyalgia. The frequency with which epileptic seizures, psychogenic non\u2010epileptic seizures, and physiological non\u2010epileptic events were comorbid with fibromyalgia was assessed. Age and gender case\u2010matched controls were used for a between\u2010group comparison. Wilcoxon tests were used to analyse interval data, and Chi\u2010square was used to analyse categorical data (<jats:italic>p<\/jats:italic>&lt;0.05). Fibromyalgia was retrospectively identified in 95\/1,730 (5.5%) patients in this cohort. Females represented 95% of the fibromyalgia sample (age: 53 years; 95% CI: 57, 51). Forty\u2010three\u00a0percent of those with fibromyalgia had a non\u2010paroxysmal, neurological primary clinical diagnosis, most commonly chronic pain. Paroxysmal events were present in 57% of fibromyalgia patients and 54% of case\u2010matched controls. Among patients with fibromyalgia and paroxysmal disorders, 11% had epileptic seizures, 74% had psychogenic non\u2010epileptic seizures, and 15% had physiological non\u2010epileptic events, compared to case\u2010matched controls with 37% epileptic seizures, 51% psychogenic non\u2010epileptic events, and 12% physiological non\u2010epileptic events (<jats:italic>p<\/jats:italic> = 0.009). Fibromyalgia was shown to be a predictor for the diagnosis of psychogenic non\u2010epileptic seizures in patients with undifferentiated paroxysmal spells. However, our results suggest that the specificity and sensitivity of fibromyalgia as a marker for psychogenic non\u2010epileptic seizures in a mixed general neurological population of patients is less than previously described.<\/jats:p>","DOI":"10.1684\/epd.2016.0823","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:29Z","timestamp":1564752269000},"page":"148-154","source":"Crossref","is-referenced-by-count":7,"title":["Fibromyalgia and seizures"],"prefix":"10.1002","volume":"18","author":[{"given":"William O.","family":"Tatum","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic  Jacksonville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Langston","sequence":"additional","affiliation":[{"name":"University of Miami College of Medicine  Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily K.","family":"Acton","sequence":"additional","affiliation":[{"name":"University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2012.11.050"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2004.12.007"},{"issue":"4","key":"e_1_2_7_4_1","first-page":"117","article-title":"Association between chronic pain or fibromyalgia and psychogenic seizures","volume":"15","author":"Benbadis S.","year":"2005","journal-title":"Am J Pain Manag"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2009.02.024"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000143273.18099.50"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b78425"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.153.1.57"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-004-0314-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3266"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000090566.40544.04"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.24"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3282f4edc3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4065\/73.8.784"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000252807.38124.a3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02927.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-013-0356-5"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2011.05.016"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530340048017"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-007-0140-5"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.NNN.0000361358.53768.86"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1535-7511.2010.01356.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22345"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e31821c3dce"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001592"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-300776"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6974(94)00014-Q"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24772"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60304-4"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2016.0823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:03:19Z","timestamp":1710777799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2016.0823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1684\/epd.2016.0823"],"URL":"https:\/\/doi.org\/10.1684\/epd.2016.0823","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]}}}