{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:33:50Z","timestamp":1761514430720},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T00:00:00Z","timestamp":1467158400000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Perampanel, a non\u2010competitive antagonist of the \u03b1\u2010amino\u20103\u2010hydroxy\u20105\u2010methyl\u20104\u2010isoxazole\u2010propionic acid receptors, is the most recent antiepileptic drug available in Spain, marketed in January\u00a02014. It was initially approved by the European Medicines Agency as adjunctive treatment for partial\u2010onset seizures in patients 12 years and older, but recently also for primary generalized tonic\u2010clonic seizures. Although clinical trials provide essential information about the drug, they do not reflect daily clinical practice. This retrospective study shows the initial experience with perampanel in 11 Spanish hospitals during its first year post\u2010commercialisation. All patients who started perampanel treatment were included, but efficacy and tolerability were only assessed in those patients with a minimum follow\u2010up period of six months. In total, 256 patients were treated with perampanel before September\u00a02014, and 253 had an observational period of one year. After six months, 216\/256 patients (84%) continued on perampanel and 180\/253 (71.1%) completed one year of treatment. The mean number of previous antiepileptic drugs used was 6.83 and the median number of concomitant antiepileptic drugs was 2. The mean perampanel dose was 7.06\u00a0mg and 8.26\u00a0mg at six and 12 months, respectively. The responder rate was 39.5% and 35.9% at both follow\u2010up points, respectively. Adverse events were experienced by 91\/253 (35.5%) and resulted in withdrawal in 37 (14.6%). The most common adverse events were somnolence, dizziness, and irritability. We found no significant differences between concomitant use of enzyme\u2010inducing and non\u2010inducing antiepileptic drugs, regarding efficacy, adverse effects, or withdrawals. Irritability was not influenced by concomitant use of levetiracetam, relative to other drugs, but was more frequently observed in patients with a history of psychiatric problems or learning disabilities.<\/jats:p>","DOI":"10.1684\/epd.2016.0824","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:29Z","timestamp":1564752269000},"page":"173-180","source":"Crossref","is-referenced-by-count":22,"title":["One\u2010year clinical experience of perampanel in Spain: a multicentre study of efficacy and tolerability"],"prefix":"10.1002","volume":"18","author":[{"given":"I\u00f1igo","family":"Garamendi\u2010Ruiz","sequence":"first","affiliation":[{"name":"Hospital Universitario Cruces  Baracaldo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Eugenia","family":"Garc\u00eda\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos  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