{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:24:50Z","timestamp":1777703090718,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T00:00:00Z","timestamp":1492560000000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Aim<\/jats:italic>. We reviewed a large surgical cohort to investigate the clinical manifestations, EEG and neuroimaging findings, and postoperative seizure outcome in patients with drug\u2010resistant parietal lobe epilepsy (PLE).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. All drug\u2010resistant PLE patients, who were investigated for epilepsy surgery at Jefferson Comprehensive Epilepsy Center between 1986 and 2015, were identified. Demographic data, seizure data, EEG recordings, brain MRI, pathological findings, and postsurgical seizure outcome were reviewed.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. In total, 18 patients (11 males and seven females) were identified. Sixteen patients (88%) had tonic\u2010clonic seizures, 12 (66%) had focal seizures with impaired awareness, and 13 (72%) described auras. Among 15 patients who had brain MRI, 14 patients (93%) had parietal lobe lesions. Only three of 15 patients (20%) who had interictal scalp EEG recordings showed parietal interictal spikes. Of 12 patients with available ictal surface EEG recordings, only three patients (25%) had parietal ictal EEG onset. After a mean follow\u2010up duration of 8.6 years, 14 patients (77.7%) showed a favourable postoperative seizure outcome.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. In patients with PLE, semiology and EEG may be misleading and brain MRI is the most valuable tool to localize the epileptogenic zone. Postsurgical seizure outcome was favourable in our patients with drug\u2010resistant parietal lobe epilepsy.<\/jats:p>","DOI":"10.1684\/epd.2017.0893","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:29Z","timestamp":1564752269000},"page":"35-39","source":"Crossref","is-referenced-by-count":19,"title":["Drug\u2010resistant parietal lobe epilepsy: clinical manifestations and surgery outcome"],"prefix":"10.1002","volume":"19","author":[{"given":"Marjan","family":"Asadollahi","sequence":"first","affiliation":[{"name":"Jefferson Comprehensive Epilepsy Center, Department of Neurology Thomas Jefferson University Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Sperling","sequence":"additional","affiliation":[{"name":"Jefferson Comprehensive Epilepsy Center, Department of Neurology Thomas Jefferson University Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin H.","family":"Rabiei","sequence":"additional","affiliation":[{"name":"Jefferson Comprehensive Epilepsy Center, Department of Neurology Thomas Jefferson University Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali A.","family":"Asadi\u2010Pooya","sequence":"additional","affiliation":[{"name":"Jefferson Comprehensive Epilepsy Center, Department of Neurology Thomas Jefferson University Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.43.534"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2010.12.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2008.2.17665"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1993.tb02591.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2015.0728"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/201651"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.07.035"},{"key":"e_1_2_7_9_1","first-page":"93","article-title":"Parietal lobe epilepsy: surgical treatment and outcome","volume":"36","author":"Kim C.H.","year":"2004","journal-title":"J Korean Neurosurg"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.33703.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2014.0648"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000500"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13110"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2012.0484"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e31826c9ebc"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.3.607"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.5.1289"},{"key":"e_1_2_7_18_1","first-page":"335","article-title":"Parietal lobe epilepsy","volume":"93","author":"Siegel A.M.","year":"2003","journal-title":"Adv Neurol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2012.8.4.243"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2017.0893","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:10:41Z","timestamp":1710778241000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2017.0893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1684\/epd.2017.0893"],"URL":"https:\/\/doi.org\/10.1684\/epd.2017.0893","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}