{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:07:08Z","timestamp":1792098428692,"version":"4.4.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T00:00:00Z","timestamp":1499817600000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe a case of a child suffering from alternating hemiplegia with a heterozygous p. E815K pathogenic variant of <jats:italic>ATP1A3<\/jats:italic>. The patient started to present abnormal eye movements in the first days of life, followed by the appearance at 2 months of dystonic episodes, and later on, by recurrent episodes of alternating hemiplegia more often on the right side. A severe epilepsy started at the age of 2 years with episodes of status epilepticus since the onset which frequently recurred, requiring admission to the intensive care unit. MRI showed bilateral mesial temporal sclerosis and a left\u2010sided ischaemic lesion. Interictal EEG showed bilateral abnormalities, whereas postictal EEG after status epilepticus showed overt slowing on the left side, suggesting a predominant involvement of ictal activity of the left hemisphere. We hypothesize that in our patient, the left hemisphere might have been more prominently affected by the pathogenetic abnormalities underlying alternating hemiplegia of childhood, rendering it more prone to early ischaemic lesions and recurrent unilateral status epilepticus. We speculate whether alternating hemiplegia of childhood shares some common pathophysiological mechanisms with familial hemiplegic migraine that may be associated with a pathogenic variant of <jats:italic>ATP1A2<\/jats:italic>.<\/jats:p>","DOI":"10.1684\/epd.2017.0913","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:29Z","timestamp":1564752269000},"page":"226-230","source":"Crossref","is-referenced-by-count":6,"title":["Alternating hemiplegia of childhood and a pathogenic variant of <i>ATP1A3<\/i>: a case report and pathophysiological considerations"],"prefix":"10.1002","volume":"19","author":[{"given":"Elena","family":"Pavlidis","sequence":"first","affiliation":[{"name":"Danish Epilepsy Centre \u2010 Epilepsihospitalet Filadelfia Dianalund"},{"name":"Child Neuropsychiatry Unit, Department of Neuroscience University of Parma Parma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Uldall","sequence":"additional","affiliation":[{"name":"Danish Epilepsy Centre \u2010 Epilepsihospitalet Filadelfia Dianalund"},{"name":"Department of Paediatrics University Hospital Rigshospitalet Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"G\u00f8bel Madsen","sequence":"additional","affiliation":[{"name":"MRI\u2010team, Department of Radiology, Centre for Functional and Diagnostic Imaging and Research Copenhagen University, Hvidovre Hospital Hvidovre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Nikanorova","sequence":"additional","affiliation":[{"name":"Danish Epilepsy Centre \u2010 Epilepsihospitalet Filadelfia Dianalund"},{"name":"Institute of Regional Health Services Research University of Southern Denmark Odense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Fabricius","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology University Hospital Rigshospitalet Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"H\u00f8genhaven","sequence":"additional","affiliation":[{"name":"Department of Neurology Odense University Hospital Odense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pisani","sequence":"additional","affiliation":[{"name":"Child Neuropsychiatry Unit, Department of Neuroscience University of Parma Parma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke S.","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Danish Epilepsy Centre \u2010 Epilepsihospitalet Filadelfia Dianalund"},{"name":"Institute of Regional Health Services Research University of Southern Denmark Odense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gardella","sequence":"additional","affiliation":[{"name":"Danish Epilepsy Centre \u2010 Epilepsihospitalet Filadelfia Dianalund"},{"name":"Institute of Regional Health Services Research University of Southern Denmark Odense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Rubboli","sequence":"additional","affiliation":[{"name":"Danish Epilepsy Centre \u2010 Epilepsihospitalet Filadelfia \/ University of Copenhagen Dianalund Denmark"},{"name":"IRCCS Institute of Neurological Sciences Bellaria Hospital Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000198505.08379.69"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(06)80003-X"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/2193-1801-2-46"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2358"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2013.08.007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.103267"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2007.00777.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq295"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-015-0335-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.04.045"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1993.tb11647.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127045"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(91)90103-R"}],"container-title":["Epileptic 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