{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T08:25:08Z","timestamp":1713601508815},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T00:00:00Z","timestamp":1509408000000},"content-version":"vor","delay-in-days":60,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Aim<\/jats:italic>. Atonic seizures are common in some epileptic syndromes beginning in infancy or early childhood but they are rarely described in epilepsy with focal seizures of structural aetiology. We aimed to characterize the electroclinical features of atonic seizures in surgically remediable paediatric patients and to study the spatiotemporal organization of the underlying epileptogenic networks.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. We retrospectively analysed two consecutive, longitudinally evaluated and surgically treated paediatric patients presenting with atonic seizures as a manifestation of pharmacoresistant epilepsy of structural aetiology, evidenced by scalp\u2010 and stereotactic intracerebral video\u2010EEG\u2010recordings. A quantitative analysis of the epileptogenic zone organization was performed using the \u201cepileptogenicity index\u201d.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Long\u2010lasting generalized ictal atonia, occurring in infancy, was a predominant clinical feature in both patients, with some hints of focal origin present in one case. The seizure phenotype evolved at later age into subtle segmental atonia, associated with prominent positive motor signs. The epileptogenic zone was localized within the dorsolateral or mesiolateral premotor region. Its spatial organization was focal, matching the lesional cortex in one and distributed involving several lesional and non\u2010lesional structures in the other case. The emergence of atonic semiology temporally correlated with involvement of both lateral and mesial premotor, as well as primary motor areas.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. We hypothesize that atonic seizures may be considered as a motor system seizure phenotype in the setting of structural epilepsy. Complete removal of the epileptogenic area provided excellent seizure control.<\/jats:p>","DOI":"10.1684\/epd.2017.0930","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:29Z","timestamp":1564752269000},"page":"315-326","source":"Crossref","is-referenced-by-count":4,"title":["Atonic seizures in children with surgically remediable epilepsy: a motor system seizure phenotype?"],"prefix":"10.1002","volume":"19","author":[{"given":"Julia","family":"Scholly","sequence":"first","affiliation":[{"name":"Medical and Surgical Epilepsy Unit, Hautepierre Hospital University of Strasbourg Strasbourg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Bartolomei","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology Department, Timone Hospital University Aix\u2010Marseille II Marseille"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Paola","family":"Valenti\u2010Hirsch","sequence":"additional","affiliation":[{"name":"Medical and Surgical Epilepsy Unit, Hautepierre Hospital University of Strasbourg Strasbourg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clotilde","family":"Boulay","sequence":"additional","affiliation":[{"name":"Medical and Surgical Epilepsy Unit, Hautepierre Hospital University of Strasbourg Strasbourg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"De Saint Martin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Strasbourg Strasbourg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Timofeev","sequence":"additional","affiliation":[{"name":"Medical and Surgical Epilepsy Unit, Hautepierre Hospital University of Strasbourg Strasbourg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Kehrli","sequence":"additional","affiliation":[{"name":"Medical and Surgical Epilepsy Unit, Hautepierre Hospital University of Strasbourg Strasbourg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Medical and Surgical Epilepsy Unit, Hautepierre Hospital University of Strasbourg Strasbourg"},{"name":"IDEE Epilepsy Institute Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1995.tb00415.x"},{"key":"e_1_2_7_3_1","volume-title":"The Epileptic Seizure. 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