{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:26:59Z","timestamp":1788319619244,"version":"build-2803163510"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Brivaracetam is currently indicated as adjunctive therapy for patients with focal\u2010onset seizures with or without secondary generalization. However, it has been suggested that it could provide broad\u2010spectrum efficacy given its similarity to levetiracetam and based on the results from preclinical studies and others of patients with generalized epilepsy. We present the case of a woman with refractory idiopathic generalized epilepsy and absence seizures with dramatic response to brivaracetam. Our report supports a consideration of treatment with this new antiepileptic drug on a case\u2010by\u2010case basis in patients with refractory generalized epilepsy, while we await further studies on this topic.<\/jats:p>","DOI":"10.1684\/epd.2017.0939","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:29Z","timestamp":1564752269000},"page":"60-64","source":"Crossref","is-referenced-by-count":13,"title":["Exceptional response to brivaracetam in a patient with refractory idiopathic generalized epilepsy and absence seizures"],"prefix":"10.1002","volume":"20","author":[{"given":"Alberto","family":"Grande\u2010Mart\u00edn","sequence":"first","affiliation":[{"name":"Department of Neurology General Hospital of Albacete Spain"},{"name":"Department of Clinical Neurophysiology General Hospital of Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sopelana\u2010Garay","sequence":"additional","affiliation":[{"name":"Department of Neurology General Hospital of Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Pardal\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology General Hospital of Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Mar\u00eda","family":"S\u00e1nchez\u2010Honrubia","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology General Hospital of Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro Abelardo","family":"S\u00e1nchez\u2010Larsen","sequence":"additional","affiliation":[{"name":"Department of Neurology General Hospital of Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13275"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000271385.85302.55"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12391"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.198"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13768"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/35087000"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2017.0939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:04:26Z","timestamp":1710777866000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2017.0939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1684\/epd.2017.0939"],"URL":"https:\/\/doi.org\/10.1684\/epd.2017.0939","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}