{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T04:10:35Z","timestamp":1769314235202,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":61,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Aim<\/jats:italic>. Idiopathic (genetic) generalized epilepsies (IGEs) are age\u2010related epileptic syndromes with typical age onset in childhood or adolescence. We report a patient with<jats:italic>de novo<\/jats:italic>late\u2010onset absence status epilepticus (ASE) occurring at the age of 64 years, with clinical and EEG features suggestive of late\u2010onset IGE. We also discuss the relationship between<jats:italic>de novo<\/jats:italic>late\u2010onset ASE and late\u2010onset IGE, and provide a comprehensive and critical review of the available literature on late\u2010onset (<jats:italic>i.e<\/jats:italic>. onset \u226560 years) IGE.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. MEDLINE (1966\u20132016 [23<jats:sup>th<\/jats:sup>April]) was systematically searched in order to identify reports of patients with late\u2010onset IGE. Grey literature was also comprehensively searched.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. We identified nine patients with electroclinical features suggestive of late\u2010onset IGE. Median age at seizure onset was 71 years (range: 60\u201380), with a female prevalence (67%). A family history of epilepsy was reported in 67% of cases. All patients had generalized tonic\u2010clonic seizures, and 44% also had myoclonic seizures. Treatment and outcome were reported for six patients; all of whom reached seizure freedom under monotherapy with valproic acid (83%) or lamotrigine (17%) (range of follow\u2010up: 3 to 24 months).<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. Late\u2010onset IGE are entities with unknown prevalence and incidence, and should be differentiated on the basis of late\u2010onset reactivation of previous IGE. Late\u2010onset IGEs are probably unrecognized or misdiagnosed, based on a common misconception that all elderly individuals with first\u2010ever seizures have focal symptomatic epilepsy. Late\u2010onset IGE should be actively investigated by accurate history taking aimed at identifying seizures, which may have been unnoticed, and familial antecedents of epilepsy. In elderly patients presenting with<jats:italic>de novo<\/jats:italic>late\u2010onset ASE, a diagnosis of late\u2010onset IGE should be considered in the differential diagnosis, particularly in atypical cases (<jats:italic>e.g<\/jats:italic>. absence of triggering factors, coexistence of generalized tonic\u2010clonic or myoclonic seizures, and interictal generalized epileptiform discharges).<\/jats:p>","DOI":"10.1684\/epd.2018.0961","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:29Z","timestamp":1564752269000},"page":"123-131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<i>De novo<\/i>late\u2010onset absence status epilepticus or late\u2010onset idiopathic generalized epilepsy? A case report and systematic review of the literature"],"prefix":"10.1002","volume":"20","author":[{"given":"Francesco","family":"Brigo","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona"},{"name":"Division of Neurology, Franz Tappeiner Hospital Merano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Tavernelli","sequence":"additional","affiliation":[{"name":"Division of Neurology, Franz Tappeiner Hospital Merano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Nardone","sequence":"additional","affiliation":[{"name":"Division of Neurology, Franz Tappeiner Hospital Merano Italy"},{"name":"Department of Neurology, Christian Doppler Medical Centre, Paracelsus Medical University, Salzburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugen","family":"Trinka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Christian Doppler Medical Centre, Paracelsus Medical University, Salzburg"},{"name":"Center for Cognitive Neuroscience, Salzburg"},{"name":"University for Health Sciences, Medical Informatics and Technology, Hall IT Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1972.tb04565.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1684\/epd.2007.0059","article-title":"Absence status in the elderly as a late complication of idiopathic generalized epilepsies","volume":"9","author":"Bauer G.","year":"2007","journal-title":"Epileptic Disord"},{"key":"e_1_2_6_4_1","first-page":"624309","article-title":"The syndrome of absence 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