{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T23:01:10Z","timestamp":1772233270913,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":61,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2018,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:italic>\n . To demonstrate the importance of averaging in time\u2010frequency space and the added localizing value in time and space in a case of cortical myoclonus.\n <\/jats:p>\n \n Methods<\/jats:italic>\n . One hundred myoclonic jerks were averaged in time series and in spectral domain. For the latter, we chose 100 (10\u2010second) segments from interictal background and used the unpaired t\u2010test for the jerk\u2010related and control spectral data to obtain the t value and corresponding\n p<\/jats:italic>\n value at each pixel. We corrected for multiple comparisons using false discovery rate procedure. We generated maps of spectral significance per electrode. All insignificant t\u2010values were converted to 0 for easier visual analysis.\n <\/jats:p>\n \n Results<\/jats:italic>\n . Standard back\u2010averaging of 100 jerks disclosed a single spike preceding EMG activity by 19\u201327 milliseconds. No other definite ictal patterns were discernible in the time domain. Statistical analysis of the same 100 epochs in the time\u2010frequency domain disclosed a greater temporal extent of the seizure, as well as a more detailed rendering of rhythms and frequencies involved. Valproate was added and led to substantial improvement.\n <\/jats:p>\n \n Conclusions<\/jats:italic>\n . Averaging in the spectral domain may reveal frequency\u2010specific changes that may not be otherwise appreciated in the time domain. Future studies may elucidate the effect on the sensitivity of diagnosis of simple partial seizures and auras.\n <\/jats:p>","DOI":"10.1684\/epd.2018.0962","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T09:24:29Z","timestamp":1564737869000},"page":"132-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Averaging in time\u2010frequency domain reveals the temporal and spatial extent of seizures recorded by scalp EEG"],"prefix":"10.1002","volume":"20","author":[{"given":"Rafeed","family":"Alkawadri","sequence":"first","affiliation":[{"name":"The Department of Neurology, School of Medicine, Yale University New Haven, CT 06520\u20138018"},{"name":"Yale Human Brain Mapping Program, Yale University New Haven CT 06520\u20138018 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Gaspard","sequence":"additional","affiliation":[{"name":"H\u00f4pital Erasme \u2010 ULB. Cliniques universitaires de Bruxelles. Route de Lennik 808 \u2010 B \u2010 1070 Bruxelles Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.10.3.134"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.1037"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-198510000-00002"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2010.05.033"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2013.0554"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.03.020"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.45703.x"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2015.08.004"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(61)90173-0"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.157.3784.92"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13120"},{"key":"e_1_2_3_14_1","first-page":"158","volume-title":"Bioelectric Recording Techniques, Part B","author":"Vaughan HG","year":"1974"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2018.0962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T12:09:57Z","timestamp":1710763797000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2018.0962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1684\/epd.2018.0962"],"URL":"https:\/\/doi.org\/10.1684\/epd.2018.0962","archive":["Portico"],"relation":{"is-cited-by":[{"id-type":"doi","id":"10.3389\/fnins.2019.00191","asserted-by":"object"}]},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"2017-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}