{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T09:55:33Z","timestamp":1721642133686},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":61,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We report a 33\u2010year\u2010old Japanese man who suffered from repetitive generalized tonic\u2010clonic seizures which were medically intractable. Neurosyphilis was serologically diagnosed in blood and cerebrospinal fluid, and penicillin G (PcG) was consequently effective. The EEG during PcG pre\u2010treatment showed frequent right occipital spikes and right frontocentral slow waves, which disappeared after treatment. During pre\u2010treatment, positron emission tomography with 18\u2010fluorodeoxyglucose and Tc\u201099m ethyl cysteinate dimer single\u2010photon emission computed tomography revealed occipital hypermetabolism and hyperperfusion (\u201chot\u201d area) and fronto\u2010temporo\u2010parietal hypometabolism and hypoperfusion (\u201ccool\u201d area) over the right hemisphere. The spike sources of magnetoencephalography during pre\u2010treatment were localized to \u201chot\u201d areas, and the slow activities were distributed to the fronto\u2010temporo\u2010parietal region, corresponding to \u201ccool\u201d areas. The inflammatory seizure focus and reversible dysfunctional zone associated with neurosyphilis were clearly delineated using these techniques.<\/jats:p>","DOI":"10.1684\/epd.2018.0967","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:29Z","timestamp":1564752269000},"page":"164-168","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Electroclinical and radiological observation of dysfunctional zones in a patient with neurosyphilis"],"prefix":"10.1002","volume":"20","author":[{"given":"Katsuya","family":"Sakai","sequence":"first","affiliation":[{"name":"Department of Neurology, Junwakai Memorial Hospital, Miyazaki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Yazawa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Junwakai Memorial Hospital, Miyazaki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Junwakai Memorial Hospital, Miyazaki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Nakao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Junwakai Memorial Hospital, Miyazaki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhito","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Department of Neurology, Junwakai Memorial Hospital, Miyazaki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Department of Radiology, Junwakai Memorial Hospital, Miyazaki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Junwakai Memorial Hospital, Miyazaki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Matsuhashi","sequence":"additional","affiliation":[{"name":"Human Brain Research Center, Kyoto University School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2004.03.007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-015-0481-x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebcr.2015.02.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1607-551X(09)70330-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30140-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-199004000-00006"},{"key":"e_1_2_7_8_1","first-page":"5","article-title":"Standardized low\u2010resolution brain electromagnetic tomography (sLORETA): technical details","volume":"24","author":"Pascual\u2010Marqui R.D.","year":"2002","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-008-0156-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2008.05.003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:BRAT.0000032864.93890.f9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310103"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2018.0967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:10:12Z","timestamp":1710778212000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2018.0967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1684\/epd.2018.0967"],"URL":"https:\/\/doi.org\/10.1684\/epd.2018.0967","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"2017-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}