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Antidepressants are recommended to treat atypical depression but are not always effective and present a certain risk of seizure provocation. Thus, new treatment options are welcome. Here, we describe three cases of refractory epilepsy with atypical depression in which olanzapine, contrary to its earlier reported proconvulsant effect, showed excellent antidepressant action and resulted in seizure control. Possible mechanisms of this action are discussed.<\/jats:p>","DOI":"10.1684\/epd.2018.0977","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:29Z","timestamp":1564752269000},"page":"225-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antiepileptic effect of olanzapine in epilepsy patients with atypical depressive comorbidity"],"prefix":"10.1002","volume":"20","author":[{"given":"Xiangmiao","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Neurology, West China Hospital Sichuan University No. 37 Guo Xue Road Chengdu Sichuan 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Zingano","sequence":"additional","affiliation":[{"name":"Centro de neuroci\u00eancias aplicadas (CeNAp) Universidade Federal de Santa Catarina (UFSC), Hospital Governador Celso Ramos (HGCR) Florian\u00f3polis SC 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