{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:55:08Z","timestamp":1787838908225,"version":"build-2784847793"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T00:00:00Z","timestamp":1542758400000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Voltage\u2010gated sodium channel alpha subunit 2 (\n                    <jats:italic>SCN2A<\/jats:italic>\n                    ) gene mutations are associated with neonatal seizures and a wide range of epilepsy syndromes. Previous reports suggest that traditional sodium channel blockers (SCBs) such as phenytoin, carbamazepine, and lamotrigine have a beneficial effect on\n                    <jats:italic>SCN2A<\/jats:italic>\n                    \u2010related neonatal seizures, as they counteract the gain\u2010of\u2010function effect of mutated Nav1.2 channels. Additionally, SCBs are beneficial against other sodium and potassium channel\u2010related neonatal seizures. There are, however, few reports describing the effect of the new SCB lacosamide against neonatal and infantile epileptic seizures. We report herein two neonates with intractable neonatal seizures with\n                    <jats:italic>SCN2A<\/jats:italic>\n                    pathogenic missense variants. Both infants showed temporary seizure relief following IV administrations of phenytoin, but were resistant to a combination of antiepileptic drugs, while complete seizure control was achieved following lacosamide administration. We suggest that SCBs,\n                    <jats:italic>e.g<\/jats:italic>\n                    . phenytoin, should be introduced early for refractory neonatal seizures of non\u2010lesional and presumably genetic origin. If any beneficial response to a SCB is noted, this should prompt an initiation of additional SCBs. New clinical trials will provide data on the efficacy and safety of the new SCB lacosamide for genetic neonatal seizures and perhaps neonatal seizures in general.\n                  <\/jats:p>","DOI":"10.1684\/epd.2018.1001","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T09:24:29Z","timestamp":1564737869000},"page":"440-446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Lacosamide for\n                    <i>SCN2A<\/i>\n                    \u2010related intractable neonatal and infantile seizures"],"prefix":"10.1002","volume":"20","author":[{"given":"Flor\u2010Hirsch","family":"Hadar","sequence":"first","affiliation":[{"name":"Pediatric Neurology and Development Center, Assaf Harofe Medical Center, Zerifin"},{"name":"Neonatolgy Unit, Assaf Harofe Medical Center, Zerifin"},{"name":"Sackler faculty of medicine, Tel Aviv University, Tel Aviv"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyman","family":"Eli","sequence":"additional","affiliation":[{"name":"Pediatric Neurology and Development Center, Assaf Harofe Medical Center, Zerifin"},{"name":"Sackler faculty of medicine, Tel Aviv University, Tel Aviv"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livneh","family":"Ayelet","sequence":"additional","affiliation":[{"name":"Neonatolgy Unit, Assaf Harofe Medical Center, Zerifin"},{"name":"Sackler faculty of medicine, Tel Aviv University, Tel Aviv"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reish","family":"Orit","sequence":"additional","affiliation":[{"name":"Sackler faculty of medicine, Tel Aviv University, Tel Aviv"},{"name":"Genetics Institute, Assaf Harofe Medical Center, Zerifin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Watemberg","family":"Nathan","sequence":"additional","affiliation":[{"name":"Sackler faculty of medicine, Tel Aviv University, Tel Aviv"},{"name":"Pediatric Neurology Unit, Meir Medical Center, Kfar\u2010Saba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Litmanovits","family":"Ita","sequence":"additional","affiliation":[{"name":"Sackler faculty of medicine, Tel Aviv University, Tel Aviv"},{"name":"Neonatology Unit, Meir Medical Center, Kfar\u2010Saba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben Sason Lilli","family":"Anat","sequence":"additional","affiliation":[{"name":"Pediatric Neurology and Development Center, Assaf Harofe Medical Center, Zerifin"},{"name":"Sackler faculty of medicine, Tel Aviv University, Tel Aviv"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lev","family":"Dorit","sequence":"additional","affiliation":[{"name":"Sackler faculty of medicine, Tel Aviv University, Tel Aviv"},{"name":"Pediatric Neurology unite, Edith Wolfson Medical Center, Holon, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lerman Sagie","family":"Tally","sequence":"additional","affiliation":[{"name":"Sackler faculty of medicine, Tel Aviv University, Tel Aviv"},{"name":"Pediatric Neurology unite, Edith Wolfson Medical Center, Holon, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassan","family":"Haim","sequence":"additional","affiliation":[{"name":"Pediatric Neurology and Development Center, Assaf Harofe Medical Center, Zerifin"},{"name":"Sackler faculty of medicine, Tel Aviv University, Tel Aviv"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12554"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2008.03.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81133-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2016.10.015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2011.02.005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01049.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2011.08.007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001926"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f8812e"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2011.09.016"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12984"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.107.039867"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2014.11.021"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7984-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12137"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx054"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2018.1001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T12:06:19Z","timestamp":1710763579000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2018.1001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1684\/epd.2018.1001"],"URL":"https:\/\/doi.org\/10.1684\/epd.2018.1001","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"2017-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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