{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:48:48Z","timestamp":1768909728819,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Aim<\/jats:italic>. Absence status epilepticus (ASE) is a prolonged generalized absence seizure that usually lasts for hours and can even last for days. The main symptom is the altered content of consciousness while the patient may be alert and partly responsive.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. We describe the electroclinical features, treatment, and evolution of three paediatric patients with <jats:italic>de novo<\/jats:italic> ASE with an excellent response to valproic acid (VPA).<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Three paediatric patients presented with non\u2010convulsive status epilepticus and an acute confusional state with impaired consciousness and EEG abnormalities compatible with typical ASE, associated with generalized spike\u2010and\u2010wave paroxysms at 2.5\u20104 Hz, as the first epileptic manifestation at eight, three, and nine years of age, respectively. No significant personal and\/or family history was reported. None of the patients had absence seizures or any other type of seizure before the occurrence of the ASE. All of them responded well to VPA and had a benign disease course. Neuroradiological imaging was normal in all patients. These three cases presented with ASE as the first manifestation of their epilepsy; none of them had any other type of seizure before the event or during their follow\u2010up, which was long\u2010term in one. All patients had an excellent response to VPA.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>. Our three cases presented with generalized typical ASE as the first manifestation of their epilepsy. <jats:italic>De novo<\/jats:italic> ASE might be considered as a well\u2010defined idiopathic epilepsy syndrome or a variant of an idiopathic generalized epilepsy syndrome, such as a particular type or variant of childhood absence epilepsy.<\/jats:p>","DOI":"10.1684\/epd.2018.1008","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:29Z","timestamp":1564752269000},"page":"502-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>De novo<\/i> absence status epilepticus in three paediatric patients: a new idiopathic epilepsy syndrome?"],"prefix":"10.1002","volume":"20","author":[{"given":"Roberto H.","family":"Caraballo","sequence":"first","affiliation":[{"name":"Hospital de Pediatr\u00eda \u201cProf. Dr. Juan P Garrahan\u201d, Buenos Aires"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Chac\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Regional de Gualeguaych\u00fa, Gualeguaych\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Fasulo","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Pedi\u00e1trica San Lucas. Neuqu\u00e9n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Bedoya","sequence":"additional","affiliation":[{"name":"Hospital de Pediatr\u00eda \u201cLa madre y el Ni\u00f1o\u201d, Formosa Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,27]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"AdamsS WongM HajiT SohailS AlmubarakS.Case reports in neurological medicine.2016.http\/\/dx.doi.org\/10.115572016\/9238310."},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1998.tb01324.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12270"},{"key":"e_1_2_5_5_1","first-page":"624309","article-title":"The syndrome of absence status epilepsy: review of the literature","volume":"2014","author":"Bilo L.","year":"2014","journal-title":"Epilepsy Res Treat"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2018.0961"},{"key":"e_1_2_5_7_1","first-page":"581","volume-title":"Handbook of Clinical Neurology, Vol. 111 (3rd series) Pediatric Neurology Part I","author":"Caraballo RH","year":"2013"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02926.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12550"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01467.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12311"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992289803700106"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00805.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.132448"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01702.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01777.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-016-0603-8"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.00316.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12269"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2018.1008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:05:38Z","timestamp":1710777938000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2018.1008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1684\/epd.2018.1008"],"URL":"https:\/\/doi.org\/10.1684\/epd.2018.1008","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"2018-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}