{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:21:05Z","timestamp":1773922865237,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The origin of faciobrachial dystonic seizures in anti\u2010LGI1 encephalitis is controversial due to a lack of neurophysiological characterization. We report a 68\u2010year\u2010old man with subacute anterograde memory loss and involuntary faciobrachial movements. Video\u2010polygraphic recordings disclosed repetitive events characterized by sudden, short contraction of the upper limbs and ipsilateral hemiface. A focal contralateral EEG slow wave from frontal or central electrodes was accompanied by increased muscle activity, often with a diamond\u2010shaped configuration, on the orbicularis oris muscle, deltoid muscle, and extensor muscle of the hand. This EEG\/EMG pattern (resembling a tonic epileptic spasm) was always followed by oral and gestural automatisms with dystonic posturing of the upper limbs, compatible with a temporal lobe seizure. Brain MRI showed hyperintensity in the bilateral mesial temporal lobes, while 18FDG\u2010PET revealed basal ganglia hypermetabolism with extensive cortical hypometabolism. Serum and CSF were both positive for anti\u2010LGI antibodies. The patient was treated with intravenous methylprednisolone (1 g\/day for five days) with seizure freedom within four days after initiation of the immunotherapy. In this case, a video\u2010EEG\/polygraphic study disclosed that faciobrachial dystonic seizures may resemble epileptic spasms, and the occurrence in close temporal association with focal seizures as a single ictal event is suggestive of a peculiar cortical\u2010subcortical interaction. [<jats:italic>Published with video sequence on<\/jats:italic><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.epilepticdisorders.com\">www.epilepticdisorders.com<\/jats:ext-link>]<\/jats:p>","DOI":"10.1684\/epd.2018.1010","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:29Z","timestamp":1564752269000},"page":"525-529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Faciobrachial dystonic seizures expressed as epileptic spasms, followed by focal seizures in anti\u2010LGI1 encephalitis: a video\u2010polygraphic study"],"prefix":"10.1002","volume":"20","author":[{"given":"Giuseppe","family":"d\u2019Orsi","sequence":"first","affiliation":[{"name":"Epilepsy Centre \u2010 Clinic of Nervous System Diseases, Riuniti Hospital, Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Martino","sequence":"additional","affiliation":[{"name":"Epilepsy Centre \u2010 Clinic of Nervous System Diseases, Riuniti Hospital, Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Lalla","sequence":"additional","affiliation":[{"name":"Epilepsy Centre \u2010 Clinic of Nervous System Diseases, Riuniti Hospital, Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa Di","family":"Claudio","sequence":"additional","affiliation":[{"name":"Epilepsy Centre \u2010 Clinic of Nervous System Diseases, Riuniti Hospital, Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Carapelle","sequence":"additional","affiliation":[{"name":"Epilepsy Centre \u2010 Clinic of Nervous System Diseases, Riuniti Hospital, Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Avolio","sequence":"additional","affiliation":[{"name":"Epilepsy Centre \u2010 Clinic of Nervous System Diseases, Riuniti Hospital, Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.15302.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-6946-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1684\/epd.2007.0114","article-title":"Adult epileptic spasms: a clinical and video\u2010polygraphic study","volume":"9","author":"d\u2019Orsi G.","year":"2007","journal-title":"Epileptic Disord"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13671"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt212"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww012"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2003.25102.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1618656114"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.28401.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22470"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2017.10.014"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2018.1010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T16:53:11Z","timestamp":1721580791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2018.1010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1684\/epd.2018.1010"],"URL":"https:\/\/doi.org\/10.1684\/epd.2018.1010","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"2018-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}