{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:54:52Z","timestamp":1782258892790,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"vor","delay-in-days":46,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We report the case of a patient suffering from pharmacotherapy\u2010resistant bilateral progressive myoclonic epilepsy (PME) showing a beneficial response upon selective deep brain stimulation (DBS) of the substantia nigra pars reticulata. As an individual experimental therapeutic approach, we implanted DBS electrodes in the transitional zone between the subthalamic nucleus (STN) and the substantia nigra pars reticulata (SNr). Electrode placement allowed for a selective stimulation of either the STN, SNr, or both targets. Postoperatively, we observed a moderate subjective and objective improvement in positive and negative myoclonus by high\u2010frequency DBS of the STN\/SNr transitional zone. However, a systematic exploration of different stimulation settings revealed that monopolar stimulation of the substantia nigra alone was more effective than high\u2010frequency monopolar DBS of either the motor STN (monopolar) or stimulation of both targets (STN\/SNr). This observation confirms earlier findings showing that patients with PME benefit from high\u2010frequency DBS. However, in contrast to previous reports stimulating the STN\/SNr transitional zone, our patient showed the most significant effect upon selective stimulation of the SNr. We propose that in patients undergoing DBS for myoclonus, at least one electrode contact should be placed in the SNr allowing for selective monopolar stimulation of this target.<\/jats:p>","DOI":"10.1684\/epd.2019.1072","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T16:28:53Z","timestamp":1706027333000},"page":"283-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Selective deep brain stimulation in the substantia nigra reduces myoclonus in progressive myoclonic epilepsy: a novel observation and short review of the literature"],"prefix":"10.1002","volume":"21","author":[{"given":"Andrea","family":"di Giacopo","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital and university of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian R.","family":"Baumann","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital and university of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kurthen","sequence":"additional","affiliation":[{"name":"Swiss Epilepsy Centre University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Capecchi","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital and university of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oguzkan","family":"S\u00fcr\u00fcc\u00fc","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas L.","family":"Imbach","sequence":"additional","affiliation":[{"name":"Department of Neurology 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