{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:14:38Z","timestamp":1779909278681,"version":"3.53.1"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"vor","delay-in-days":59,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Aims<\/jats:italic>. To delineate common epilepsy features associated with the presence of glutamic acid decarboxylase autoantibodies (GAD65\u2010Ab).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. Three consecutive cases of GAD65\u2010Ab encephalitis patients, followed in our neurological department, were investigated with regards to clinical semiology and EEG.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. These patients presented new\u2010onset subtle ictal clinical features. Patients 1 and 2 described prolonged and transitory feelings of \u201c<jats:italic>d\u00e9j\u00e0 vu<\/jats:italic> \u2010 <jats:italic>d\u00e9j\u00e0 v\u00e9cu<\/jats:italic>\u201d and a \u201c<jats:italic>dreamy state<\/jats:italic>\u201d. Patient 3 was admitted for subsequent transient aphasia events followed by paroxysmal behavioural disturbances.<\/jats:p><jats:p>Epileptic origin of the symptoms was confirmed using either a standard EEG (observation of temporal status epilepticus in one case) or a prolonged EEG (focal epileptiform activity during an asymptomatic period for two patients). All patients suffered from clinical focal status epilepticus. Patients 1 and 2 presented with temporo\u2010mesial seizures in agreement with the definition for limbic encephalitis, whereas Patient 3 presented with neocortical (lateral temporal and frontal lobe) seizures arguing for a non\u2010limbic encephalitis. A high level of GAD65\u2010Ab was found in cerebral spinal fluid, confirming a diagnosis of epilepsy associated with GAD65\u2010Ab encephalitis.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. Encephalitis seems to be a frequent neurological syndrome associated with GAD65\u2010Ab disorders. Epilepsy may be more frequent and severe than currently suggested, as ictal semiology may be subtle for these outpatients in whom standard EEG is commonly falsely reassuring. Subtle focal status epilepticus is a particular semiology of the GAD65\u2010Ab encephalitis spectrum.<\/jats:p>","DOI":"10.1684\/epd.2019.1094","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T16:27:45Z","timestamp":1706027265000},"page":"437-442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["GAD65\u2010Ab encephalitis and subtle focal status epilepticus"],"prefix":"10.1002","volume":"21","author":[{"given":"Mathilde","family":"Goudot","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospital of Nancy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol\u00e8ne","family":"Frismand","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Nancy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Hopes","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Nancy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Verger","sequence":"additional","affiliation":[{"name":"Department of Nuclear medicine, University Hospital of Nancy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastien","family":"Joubert","sequence":"additional","affiliation":[{"name":"French Reference Center of Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Department of Neurology, INSERM U1217\/CNRS, UMR5310, Lyon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Honnorat","sequence":"additional","affiliation":[{"name":"French Reference Center of Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Department of Neurology, INSERM U1217\/CNRS, UMR5310, Lyon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Tyvaert","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Nancy"},{"name":"University of Lorraine Faculty of Medicine CRAN CNRS UMR 7039 Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12127"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.3499"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.01.021"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03609.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2016.13"},{"issue":"1","key":"e_1_2_6_7_1","first-page":"227","article-title":"Autoimmune epilepsy","volume":"22","author":"Gaspard N.","year":"2016","journal-title":"Continuum (Minneap Minn)"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00401-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.2.225"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21917"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2011.03.038"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn183"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.04.046"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.03.004"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2019.1094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:14:24Z","timestamp":1710778464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2019.1094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1684\/epd.2019.1094"],"URL":"https:\/\/doi.org\/10.1684\/epd.2019.1094","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"2018-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}