{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T18:23:47Z","timestamp":1766514227485},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Aims<\/jats:italic>\n            : Lacosamide (LCM) is a well\u2010tolerated and increasingly used second\u2010generation AED, and side effects such as atrial fibrillation are rare and poorly characterized. Supported by a literature review, we share our experience of the management of the first reported case of cardioembolic cerebral infarcts in the context of\n            <jats:italic>de novo<\/jats:italic>\n            atrial fibrillation, which appeared following a 200\u2010mg intravenous infusion of LCM for the treatment of non\u2010convulsive status epilepticus.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Methods<\/jats:italic>\n            : Case report and literature review using search items including \u201catrial fibrillation OR atrial flutter AND LCM\u201d in the thesaurus of Medline.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Results<\/jats:italic>\n            : We found three cases of atrial fibrillation\/atrial flutter secondary to LCM, one following a 200\u2010mg intravenous infusion. In one patient, previous risk factors for atrial fibrillation were reported and another was started on warfarin; all required suspension of LCM for cessation of atrial fibrillation. Previous risk factors for atrial fibrillation in our patient were older age, male gender, obesity, hypertension, valvular disease, first\u2010degree atrioventricular block and left anterior fascicle block. Atrial fibrillation appeared at the end of the infusion and ceased after a loading dose of amiodarone and suspension of LCM. Apixaban was initiated indefinitely five days later, and MRI showed four acute silent infarctions.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusions<\/jats:italic>\n            : The appearance of atrial fibrillation has severe therapeutic and clinical implications and the use of LCM might be reconsidered within a context of increased predisposition to developing atrial fibrillation. If atrial fibrillation appears, the drug should be discontinued and anticoagulation should be considered according to embolic risk. Further investigation is needed in order to better categorize the risk profile of lacosamide regarding atrial fibrillation.\n          <\/jats:p>","DOI":"10.1684\/epd.2020.1136","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T14:59:40Z","timestamp":1711551580000},"page":"83-89","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cardioembolic acute cerebral micro\u2010infarcts in the context of atrial fibrillation after low\u2010dose intravenous infusion of lacosamide"],"prefix":"10.1002","volume":"22","author":[{"given":"\u00c1lvaro Beltr\u00e1n","family":"Corbellini","sequence":"first","affiliation":[{"name":"Department of Neurology Hospital Universitario Ram\u00f3n y Cajal. Madrid  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula P\u00e9rez","family":"Torre","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitario Ram\u00f3n y Cajal. Madrid  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Velina Nedkova","family":"Hristova","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitario Ram\u00f3n y Cajal. Madrid  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz Zarza","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitario Ram\u00f3n y Cajal. Madrid  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Celdr\u00e1n de Castro","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitario Ram\u00f3n y Cajal. Madrid  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Rodriguez","family":"Jorge","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitario Ram\u00f3n y Cajal. Madrid  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Lu\u00eds Chico","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitario Ram\u00f3n y Cajal. Madrid  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma Parra","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitario Ram\u00f3n y Cajal. Madrid  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier Buisan","family":"Catevilla","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitario Ram\u00f3n y Cajal. Madrid  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,13]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","first-page":"132","article-title":"Antiepileptic drugs","volume":"22","author":"Abou\u2010Khalil B.W.","year":"2016","journal-title":"Continuum (Minneap Minn)"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.490896"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510350050036"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01188.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02496.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2010.04.043"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03543.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2013.03.023"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.81a.13148"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7967-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01951.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2064027"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebcr.2012.10.006"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw210"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2011.02.006"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001760"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2015.05.007"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2013.12.020"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2013.06.012"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.06.008"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03212.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2014.11.021"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.1.113"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.01.322"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2016.10.001"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13716"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2012.05.012"},{"key":"e_1_2_8_30_1","unstructured":"UCB Pharma.Vimpat Prescribing Information. June2019."},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000141"},{"issue":"1","key":"e_1_2_8_32_1","first-page":"69","article-title":"Cardiac arrhythmias during or after epileptic seizures","volume":"87","author":"Van der Lende M.","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001123"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e318196d2b6"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2020.1136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T16:48:40Z","timestamp":1711558120000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2020.1136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1684\/epd.2020.1136"],"URL":"https:\/\/doi.org\/10.1684\/epd.2020.1136","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"2019-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}