{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T03:31:15Z","timestamp":1784086275397,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":61,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Ring chromosome 20 syndrome is an epileptic and neurodevelopmental encephalopathy that occurs in children, characterised by a triad of refractory frontal lobe seizures, recurrent non\u2010convulsive status epilepticus and frontal lobe\u2010dominant paroxysmal discharges. However, details of other clinical features associated with ring chromosome 20 syndrome remain unknown. Here, we report two patients with ring chromosome 20 syndrome who had praxis\u2010induced reflex seizures.<\/jats:p><jats:p><jats:italic>Case 1<\/jats:italic> was an 11\u2010year\u2010old girl who presented with seizures triggered by specific activities such as mental and written calculations, writing, decision\u2010making, recall, sudden changes in routine or ambient temperature and bathing. During calculations, left frontal lobe\u2010dominant, 3\u2010Hz slow\u2010wave bursts were observed on EEG. Lacosamide effectively suppressed her tonic seizures.<\/jats:p><jats:p><jats:italic>Case 2<\/jats:italic> was a six\u2010year\u2010old boy who presented with seizures triggered by specific activities such as calculations, recall and bathing. During calculations, frontal lobe\u2010dominant, 3\u2010Hz spike and slow\u2010wave bursts were observed on EEG. Although his epilepsy was refractory, gabapentin reduced the frequency of focal seizures.<\/jats:p><jats:p>In both cases, the hyperexcitability in the frontal lobe may have spread to the motor cortex and precipitated praxis\u2010induced seizures. Therefore, in addition to the known characteristic triad, praxis\u2010induced reflex seizures may also be a feature of ring chromosome 20 syndrome.<\/jats:p>","DOI":"10.1684\/epd.2020.1146","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T13:28:31Z","timestamp":1602768511000},"page":"214-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Praxis\u2010induced reflex seizures in two Japanese cases with ring chromosome 20 syndrome"],"prefix":"10.1002","volume":"22","author":[{"given":"Hirokazu","family":"Yamagishi","sequence":"first","affiliation":[{"name":"Department of Paediatrics Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahide","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Osaka","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Kuwajima","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Yamagata","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.2.186"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh446"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703380"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2017.12.001"},{"key":"e_1_2_6_6_1","volume-title":"Epileptic syndromes in infancy, childhood and adolescence","author":"Genton P.","year":"2019"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2002000400022"},{"key":"e_1_2_6_8_1","volume-title":"Epileptic seizures and syndromes","author":"Inoue Y.","year":"1994"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.6.939"},{"key":"e_1_2_6_10_1","volume-title":"Reflex epilepsies: progress in understanding","author":"Inoue Y.","year":"2004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1550059415593428"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00227.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1995.tb01623.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2016.10.004"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02176.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12729"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2014.01.011"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2006.03.013"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2020.1146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:31:06Z","timestamp":1710779466000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2020.1146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1684\/epd.2020.1146"],"URL":"https:\/\/doi.org\/10.1684\/epd.2020.1146","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"2019-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}