{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T14:07:21Z","timestamp":1762956441894},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T00:00:00Z","timestamp":1600473600000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neurocysticercosis is a neglected and usually poverty\u2010related disease of high public importance. The mechanisms by which the calcified lesions cause epilepsy are not known, but have been attributed to residual perilesional gliosis or an inflammatory process. This case shows that an inflammatory response to a calcified granuloma may be associated with the development of epilepsy. The increase in glutamate and kinin B1 (pro\u2010epileptogenic) receptors added by reduced expression of kinin B2 (anti\u2010epileptogenic) receptors may explain the chronic epileptogenesis associated with the lesion, corroborating the hypothesis of inflammatory mechanisms involved in the pathophysiology of epilepsy in these patients.<\/jats:p>","DOI":"10.1684\/epd.2020.1188","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T08:08:40Z","timestamp":1599120520000},"page":"506-510","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neurocysticercosis and pharmacoresistant epilepsy: possible role of calcified lesions in epileptogenesis"],"prefix":"10.1002","volume":"22","author":[{"given":"Marcelo Freitas","family":"Schmid","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo\/SP 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