{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:52:18Z","timestamp":1785462738126,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Aims<\/jats:italic>. To better understand the electroclinical features and epileptic network of lateral and medial orbitofrontal epilepsy (OFE).<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. We evaluated four patients who had undergone epilepsy surgery. Epileptic foci in two patients originated from the lateral orbitofrontal cortex, and those in the other two originated from the medial orbitofrontal cortex, which was confirmed by stereoelectroencephalography (SEEG). Time\u2010frequency spectrograms were also provided for assistance, and the change in high\u2010frequency energy was superimposed on the 3D reconstructed brain with a colour code in order to more intuitively show the transfer of high\u2010frequency energy as the seizure evolves. All patients underwent SEEG\u2010guided radiofrequency thermocoagulation (RF\u2010TC) or focal resection and achieved satisfactory results.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Lateral OFE and medial OFE were relatively independent with regards to clinical symptoms and epileptic network, however, lateral OFE was likely to propagate to the dorsolateral frontal lobe, whereas medial OFE (gyrus rectus) was more likely to propagate to the medial temporal lobe or insular lobe with long duration. There were significant differences in duration (21.17 \u00b1 11.5 vs. 127.22 \u00b1 235.05) and early propagation time (7.92 \u00b1 4.44 vs. 29.0 \u00b1 33.47) between the two origins.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. A better understanding of the electroclinical features of lateral and medial OFE is helpful to understand their epileptic networks and perform accurate resections in order to protect the cognitive and behavioural functions of patients.<\/jats:p>","DOI":"10.1684\/epd.2020.1230","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T11:17:34Z","timestamp":1609845454000},"page":"759-767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Electroclinical features of lateral and medial orbitofrontal epilepsy: a case series"],"prefix":"10.1002","volume":"22","author":[{"given":"Yiou","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Epilepsy Center Tsinghua University Yuquan Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epilepsy Center Tsinghua University Yuquan Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epilepsy Center Tsinghua University Yuquan Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuluan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Epilepsy Center Tsinghua University Yuquan Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Epilepsy Center Tsinghua University Yuquan Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Epilepsy Center Tsinghua University Yuquan Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epilepsy Center Tsinghua University Yuquan Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Epilepsy Center Tsinghua University Yuquan Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.58404.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.26599\/BSA.2019.9050015"},{"key":"e_1_2_8_4_1","first-page":"55","volume-title":"Intractable Focal Epilepsy","author":"Bartolomei F","year":"2000"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn111"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2005.05.013"},{"issue":"10","key":"e_1_2_8_7_1","first-page":"1171","article-title":"Multimodal imaging reveals the role of activity in eating\u2010reflex seizures","volume":"82","author":"Blauwblomme T.","year":"2011","journal-title":"J Neurol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12490"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.3.220"},{"issue":"1","key":"e_1_2_8_10_1","first-page":"115","article-title":"The clinical signs and symptoms of frontal lobe seizures. 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