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We present one representative complex case that was discussed. The patient had seizures displaying startle\/reflex components. He was MRI negative, while other non\u2010invasive investigations offered only partially concordant data. Initial SEEG exploration resulted in an incomplete definition of the epileptogenic zone. A second SEEG followed, which led to a thorough assessment of the seizure onset zone and the epileptic network, localised to the lateral inferior premotor cortex, explaining the incongruent data obtained beforehand. This was the basis of a tailored resection with a favourable outcome. The patient has been seizure\u2010free for five years without any motor nor cognitive deficits, but with pharmacodependence to one AED. The electroclinical reasoning is presented, accompanied by relevant commentaries and recommendations from the tutors [<jats:italic>Published with video sequences<\/jats:italic>].<\/jats:p>","DOI":"10.1684\/epd.2021.1246","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T13:11:02Z","timestamp":1615813862000},"page":"180-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["SEEG re\u2010exploration in a patient with complex frontal epilepsy with rapid perisylvian propagation and mixed \u201cstartle \u2010 reflex\u201d seizures"],"prefix":"10.1002","volume":"23","author":[{"given":"Mihai Dragos","family":"Maliia","sequence":"first","affiliation":[{"name":"Van Gogh Epilepsy Surgery Unit, Neurology Department  CIC 1414, University Hospital Rennes France"},{"name":"Physics Department University of Bucharest  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Kahane","sequence":"additional","affiliation":[{"name":"Neurology Department Grenoble University Hospital  Grenoble France"},{"name":"Grenoble Neuroscience Institute Grenoble Alpes University  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Nica","sequence":"additional","affiliation":[{"name":"Van Gogh Epilepsy Surgery Unit, Neurology Department  CIC 1414, University Hospital Rennes France"},{"name":"Laboratory of Signal and Image Analysis, INSERM U1099 University Rennes 1  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Mindruta","sequence":"additional","affiliation":[{"name":"Neurology Department University Emergency Hospital  Bucharest Romania"},{"name":"Neurology Department Carol Davila University of Medicine and Pharmacy  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Castana","sequence":"additional","affiliation":[{"name":"Claudio Munari Epilepsy Surgery Centre, Neurosciences Department GOM Niguarda Hospital  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cardinale","sequence":"additional","affiliation":[{"name":"Claudio Munari Epilepsy Surgery Centre, Neurosciences Department GOM Niguarda Hospital  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Francione","sequence":"additional","affiliation":[{"name":"Claudio Munari Epilepsy Surgery Centre, Neurosciences Department GOM Niguarda Hospital  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Invasive EEG in the definition of the seizure onset zone: depth electrodes. 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