{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:25:42Z","timestamp":1791959142715,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":75,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The study of dementia and epilepsy may provide particular insight into behavioural alterations. We describe a rare case of ictal aggressive behaviour in a patient with focal epilepsy associated with a non\u2010dominant dorso\u2010lateral prefrontal lesion. During focal seizures, our patient showed intense agitation and anger, for a long time misinterpreted as psychogenic attacks, which disappeared after epilepsy surgery. The defined anatomical origin of such ictal emotional behaviour is not fully understood, however, the dorso\u2010lateral prefrontal area appears to correlate less frequently with aggressiveness compared to the antero\u2010mesial area. We describe the electroclinical data of our patient and provide a brief review of the mechanisms underlying aggressive conduct in epilepsy and dementia. An understanding of this mechanism could help to clarify the neural basis and treatment of violence associated with these and other neurological disorders. [<jats:italic>Published with video sequence<\/jats:italic>].<\/jats:p>","DOI":"10.1684\/epd.2021.1277","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T13:30:49Z","timestamp":1620912649000},"page":"419-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rage and aggressive behaviour in frontal lobe epilepsy: description of a case and review of the mechanisms of aggressive behaviour in epilepsy and dementia"],"prefix":"10.1002","volume":"23","author":[{"given":"Roberta","family":"Di Giacomo","sequence":"first","affiliation":[{"name":"Epilepsy Unit Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Didato","sequence":"additional","affiliation":[{"name":"Epilepsy Unit Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Belcastro","sequence":"additional","affiliation":[{"name":"Neurology Unit Maggiore Hospital Lodi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Deleo","sequence":"additional","affiliation":[{"name":"Epilepsy Unit Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Pastori","sequence":"additional","affiliation":[{"name":"Epilepsy Unit Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Arnaldi","sequence":"additional","affiliation":[{"name":"Division of Clinical Neurophysiology and Epilepsy Center IRCCS Ospedale Policlinico San Martino Genova Italy"},{"name":"Neurology Clinic University of Genova Medical School, Ospedale Policlinico IRCCS San Martino Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppa Jolanda","family":"Rosa","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Department of Neurosciences and Rehabilitation University of Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Villani","sequence":"additional","affiliation":[{"name":"Epilepsy Unit Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy"},{"name":"Division of Clinical Neurophysiology and Epilepsy Center IRCCS Ospedale Policlinico San Martino Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh628"},{"key":"e_1_2_6_3_1","first-page":"667","article-title":"Epilepsy and homicide","volume":"9","author":"Pandya N.S.","year":"2013","journal-title":"Neuropsychiatr Dis Treat"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198109173051231"},{"key":"e_1_2_6_6_1","volume-title":"Psychiatric issues in epilepsy: a practical guide to diagnosis and treatment","author":"Kanner A.M.","year":"2001"},{"issue":"3","key":"e_1_2_6_7_1","first-page":"161","article-title":"Epilepsy with aggressive behavior. 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