{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T11:12:31Z","timestamp":1762686751421},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":75,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE) is a recently recognized, highly epileptogenic, distinct histopathological entity in drug\u2010resistant epilepsy that primarily involves the frontal lobes. Surgical outcomes in MOGHE are variable. Although the diagnosis is based on histopathology, high\u2010resolution MRI helps to differentiate MOGHE preoperatively from other forms of cortical malformations (<jats:italic>i.e<\/jats:italic>., mMCD II and FCD IIa). We discuss the clinical, electrographic, radiological and histopathological characteristics of MOGHE in two patients who underwent evaluation for drug\u2010resistant epilepsy followed by electrocorticography\u2010based resection. Both patients presented with childhood\u2010onset refractory frontal lobe epilepsy with a high seizure burden. Interictal epileptiform discharges were widespread. PET abnormalities were disproportionate to the MRI findings. Cognitive impairment, persistent epileptiform discharges on post\u2010resection electrocorticography and sub\u2010optimal surgical outcomes suggest that MOGHE is a widespread pathology in focal epilepsy.<\/jats:p>","DOI":"10.1684\/epd.2021.1280","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T13:30:49Z","timestamp":1620912649000},"page":"407-411","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE): a widespread disease with an apparently focal epilepsy"],"prefix":"10.1002","volume":"23","author":[{"given":"Raghavendra","family":"Seetharam","sequence":"first","affiliation":[{"name":"Department of Neurology Vikram Hospital Bangalore Karanataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javeria","family":"Nooraine","sequence":"additional","affiliation":[{"name":"Department of Neurology Vikram Hospital Bangalore Karanataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radhika","family":"Mhatre","sequence":"additional","affiliation":[{"name":"Department of Neuropathology National Institute of Mental Health and Neuro Sciences Bangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaychandran","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Neurology Vikram Hospital Bangalore Karanataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh B.","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Neurology Vikram Hospital Bangalore Karanataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Mahadevan","sequence":"additional","affiliation":[{"name":"Department of Neuropathology National Institute of Mental Health and Neuro Sciences Bangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12347"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.07.009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1522"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13142"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000487088"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370410"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt299"},{"key":"e_1_2_8_9_1","article-title":"Epileptic patient with mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE): a case report and review of the literature","volume":"2019","author":"Verentzioti A.","year":"2019","journal-title":"Case Rep Neurol Med"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1252304"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5414\/NP300536"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.03.002"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2021.1280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:08:25Z","timestamp":1710778105000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2021.1280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1684\/epd.2021.1280"],"URL":"https:\/\/doi.org\/10.1684\/epd.2021.1280","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"2020-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}