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Such dysfunction is also observed in an animal model of TLE, the rat model of pilocarpine\u2010induced epilepsy.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>. We investigated the effects of fish oil supplementation on spatial memory in rats with pilocarpine\u2010induced epilepsy using the Morris Water Maze (MWM) test.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Although rats with pilocarpine\u2010induced epilepsy treated with fish oil learned the platform location significantly faster by Day 7 of the acquisition phase, spatial memory performance of these rats was unaffected by fish oil supplementation during probe trials.<\/jats:p><jats:p><jats:italic>Significance<\/jats:italic>. Our study provides insights into the importance of considering nutraceutical strategies for enhancing cognitive abilities in patients with TLE.<\/jats:p>","DOI":"10.1684\/epd.2021.1289","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T13:07:43Z","timestamp":1626181663000},"page":"476-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of fish oil supplementation on spatial memory in rats with pilocarpine\u2010induced epilepsy assessed using the Morris Water Maze test"],"prefix":"10.1002","volume":"23","author":[{"given":"Mariana Bocca","family":"Nejm","sequence":"first","affiliation":[{"name":"Disciplina de Neuroci\u00eancia, Departamento de Neurologia e Neurocirurgia, Escola Paulista de Medicina Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniella 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