{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:54:17Z","timestamp":1787838857120,"version":"build-2784847793"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the case of a previously healthy newborn who developed super\u2010refractory status epilepticus after Group B streptococcal meningoencephalitis. After administration of first\u2010, second\u2010 and third\u2010line anticonvulsants without resolution of status epilepticus, we started intravenous lacosamide as adjunctive therapy to phenobarbital, phenytoin and continuous infusion of ketamine and midazolam. After administration of lacosamide, we observed a clear\u2010cut improvement in the neurological clinical condition coupled with seizure control on continuous video\u2010EEG monitoring, even after suspension of all other medications except for phenobarbital. No adverse effects ascribable to lacosamide were reported. The available data regarding the use of lacosamide for status epilepticus in adults and children are promising, although there is as yet only anecdotal evidence for neonatal status epilepticus. Its lack of potential interactions, good tolerability and the option of intravenous use lend to its appeal as treatment for status epilepticus. To the best of our knowledge, this is one of the first reported cases of effective lacosamide infusion in neonatal\u2010onset super\u2010refractory status epilepticus. This evidence should prompt further investigation on efficacy and safety of lacosamide to support its use in this population.<\/jats:p>","DOI":"10.1684\/epd.2021.1307","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T13:02:14Z","timestamp":1627563734000},"page":"655-660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy of lacosamide in neonatal\u2010onset super\u2010refractory status epilepticus: a case report"],"prefix":"10.1002","volume":"23","author":[{"given":"Veronica","family":"Bertozzi","sequence":"first","affiliation":[{"name":"Department of Woman's and Child's Health Padova University Hospital Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia M.","family":"Bonardi","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit, Department of Woman's and Child's Health Padova University Hospital Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Biscalchin","sequence":"additional","affiliation":[{"name":"Department of Woman's and Child's Health Padova University Hospital Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa","family":"Tona","sequence":"additional","affiliation":[{"name":"Department of Woman's and Child's Health Padova University Hospital Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Amigoni","sequence":"additional","affiliation":[{"name":"Paediatric Intensive Care Unit, Department of Woman's and Child's Health Padova University Hospital Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Sartori","sequence":"additional","affiliation":[{"name":"Paediatric Neurology and Neurophysiology Unit, Department of Woman's and Child's Health Padova University Hospital Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr215"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.03.035"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-019-0546-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.222550499"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03297.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01285.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.04.038"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2018.01.014"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13716"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2017.09.019"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12414"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2017.13.2.138"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2015.12.013"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2018.1001"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2021.1307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:13:47Z","timestamp":1710778427000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2021.1307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1684\/epd.2021.1307"],"URL":"https:\/\/doi.org\/10.1684\/epd.2021.1307","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"2020-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}