{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:22:10Z","timestamp":1787023330612,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We describe the pathophysiological consequences and long\u2010term neurological outcome of a patient with acute brain injury (ABI) in whom intracortical electroencephalography (iEEG) captured an episode of prolonged focal non\u2010convulsive status epilepticus (NCSE) that remained undetectable on scalp electroencephalography. A 53\u2010year\u2010old right\u2010handed woman was admitted to hospital due to a large frontal left intraparenchymal hematoma. Over two and a half days, we captured recurrent non\u2010convulsive electrographic and electroclinical seizures compatible with the diagnosis of intracortical focal NCSE. The patient remained sedated and a burst\u2010suppression pattern was obtained. We also performed invasive brain multimodality monitoring including iEEG and measurements of intracranial pressure (ICP), partial brain tissue oxygenation (PbtO\n                    <jats:sub>2<\/jats:sub>\n                    ) and brain temperature. During non\u2010convulsive electrographic and electroclinical seizures, the values of PbtO\n                    <jats:sub>2<\/jats:sub>\n                    decreased and those of ICP increased. Six months later, brain MRI revealed encephalomalacia localized to the left paramedial fronto\u2010basal region. The neuropsychological assessment carried out one year after the injury showed scores below average in verbal learning memory, motor dexterity and executive functions. In summary, iEEG is a feasible innovative invasive technique that may be used to record non\u2010convulsive electrographic and electroclinical seizures which remain invisible on the surface. Intracortical focal NCSE causes metabolic changes such as reduced brain oxygenation and an increase in ICP that can further damage previously compromised brain tissue.\n                  <\/jats:p>","DOI":"10.1684\/epd.2021.1348","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T01:52:20Z","timestamp":1640137940000},"page":"911-916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intracortical focal non\u2010convulsive status epilepticus causing cerebral hypoxia and intracranial hypertension"],"prefix":"10.1002","volume":"23","author":[{"given":"Jos\u00e9 L.","family":"Fern\u00e1ndez\u2010Torre","sequence":"first","affiliation":[{"name":"Department of Clinical Neurophysiology Marqu\u00e9s de Valdecilla University Hospital  Santander Cantabria Spain"},{"name":"Department of Physiology and Pharmacology, School of Medicine University of Cantabria  Santander Cantabria Spain"},{"name":"Biomedical Research Institute (IDIVAL)  Santander Cantabria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Hern\u00e1ndez\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute (IDIVAL)  Santander Cantabria Spain"},{"name":"Department of Intensive Medicine Marqu\u00e9s de Valdecilla University Hospital  Santander Cantabria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mato\u2010Ma\u00f1as","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute (IDIVAL)  Santander Cantabria Spain"},{"name":"Department of Neurosurgery Marqu\u00e9s de Valdecilla University Hospital  Santander Cantabria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Marco de Lucas","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute (IDIVAL)  Santander Cantabria Spain"},{"name":"Department of Radiology Marqu\u00e9s de Valdecilla University Hospital  Santander Cantabria Spain"},{"name":"Department of Medical\u2010Surgical Sciences, School of Medicine University of Cantabria  Santander Cantabria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"G\u00f3mez\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute (IDIVAL)  Santander Cantabria Spain"},{"name":"Department of Psychiatry Marqu\u00e9s de Valdecilla University Hospital Santander  Cantabria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"Mart\u00edn\u2010L\u00e1ez","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute (IDIVAL)  Santander Cantabria Spain"},{"name":"Department of Neurosurgery Marqu\u00e9s de Valdecilla University Hospital  Santander Cantabria 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