{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:16:11Z","timestamp":1768292171889,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present an illustrative case to address anterior temporal lobe atrophy with poor delineation of the temporopolar gray\u2010white matter interface based on T2\u2010weighted and fluid\u2010attenuated inversion recovery (FLAIR) images in patients with temporal lobe epilepsy associated with hippocampal sclerosis (TLE\u2010HS). A 52\u2010year\u2010old woman with pharmacoresistant seizures since the age of six months underwent a previous MRI scan using a suboptimal protocol which was reported as unremarkable. MRI performed according to an epilepsy protocol showed classic signs of left HS and ipsilateral temporal polar atrophy with blurring of the gray\u2010white matter boundary on FLAIR images. She underwent a left amygdalohippocampectomy and anterior temporal resection and remains seizure\u2010free after 24 months. Histopathological analyses showed HS and no signs of focal cortical dysplasia (FCD). Blurring and atrophy of the ipsilateral temporal pole are common in TLE\u2010HS and often misinterpreted as FCD. This relates to delayed myelination in patients with seizures before the age of two, is more pronounced on FLAIR sequences, and gives a false impression of cortical thickening. However, the T1\u2010weighted images show a relatively well\u2010demarcated cortical\u2010subcortical transition and normal cortical thickness. By contrast, the cortical thickening in FCD is observed on both T1\u2010weighted and FLAIR images. Since FCD also occurs in temporal lobe regions, it is important to differentiate the extra\u2010hippocampal MRI abnormalities in TLE\u2010HS from those likely to be FCD. This case highlights the importance of evaluation based on detailed imaging, which should always be conducted considering the EEG, seizure semiology, and other clinical information.<\/jats:p>","DOI":"10.1684\/epd.2021.1378","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T11:53:42Z","timestamp":1643975622000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Imaging characteristics of temporopolar blurring in the context of hippocampal sclerosis"],"prefix":"10.1002","volume":"24","author":[{"given":"Carlos Andr\u00e9s","family":"Clavijo Prado","sequence":"first","affiliation":[{"name":"Department of Neurology University of Campinas \u2013 UNICAMP  Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Federico","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, Cumming School of Medicine University of Calgary  Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre and Montreal Neurological Institute and Hospital McGill University  Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis lab, McConnell Brain Imaging Centre and Montreal Neurological Institute McGill University  Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Caciagli","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Pennsylvania, Philadelphia, USA and Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Concha","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology Universidad Nacional Autonoma de Mexico  Queretaro 76230 Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yotin","family":"Chinvarun","sequence":"additional","affiliation":[{"name":"Phramongkutklao Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme","family":"Jackson","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health and The University of Melbourne  Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Morgan","sequence":"additional","affiliation":[{"name":"Vanderbilt University Institute of\u00a0Imaging\u00a0Science, Vanderbilt University Medical Center  Nashville USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Rampp","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Erlangen, Germany and Department of Neurosurgery University Hospital Halle (Saale)  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Elisabetta","family":"Vaudano","sequence":"additional","affiliation":[{"name":"Neurology Unit University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Wang","sequence":"additional","affiliation":[{"name":"Epilepsy Center Cleveland Clinic  Cleveland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Affiliated Hospital, School of Medicine Zhejiang University  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Cunha","family":"Zaidan","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Campinas \u2013 UNICAMP  Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Rogerio","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Campinas \u2013 UNICAMP  Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Cendes","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas \u2013 UNICAMP  Campinas SP 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