{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:33:26Z","timestamp":1790282006650,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":67,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epileptic negative myoclonus (ENM) is a rarely reported clinical seizure semiology. It is defined as a brief interruption of tonic muscle activity in association with an epileptiform discharge on the EEG (spike or sharp wave) without preceding myoclonia. The diagnosis of ENM requires a polygraphic recording with EEG and surface EMG electrodes covering the affected body part(s), while the muscles have tonic activity. Historically, ENM has been reported in a variety of chronic epilepsy syndromes such as benign epilepsy with centrotemporal spikes, progressive myoclonic epilepsy syndromes, symptomatic partial epilepsy syndromes due to structural pathologies, cryptogenic epilepsies, <jats:italic>etc<\/jats:italic>. In this paper, we report a patient with herpes simplex virus encephalitis who presented with multiple different seizure types including ENM. The patient showed significant improvement after treatment with acyclovir.<\/jats:p>","DOI":"10.1684\/epd.2021.1401","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T06:41:35Z","timestamp":1653115295000},"page":"417-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Epileptic negative myoclonus in herpes simplex virus encephalitis"],"prefix":"10.1002","volume":"24","author":[{"given":"Neel","family":"Fotedar","sequence":"first","affiliation":[{"name":"Epilepsy Center, Neurological Institute University Hospitals Cleveland Medical Center Cleveland OH USA"},{"name":"Case Western Reserve University School of Medicine Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Dolbow","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Neurological Institute University Hospitals Cleveland Medical Center Cleveland OH USA"},{"name":"Case Western Reserve University School of Medicine Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhura","family":"Layfield","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Neurological Institute University Hospitals Cleveland Medical Center Cleveland OH USA"},{"name":"Case Western Reserve University School of Medicine Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraj","family":"Thyagaraj","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Neurological Institute University Hospitals Cleveland Medical Center Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Zande","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Neurological Institute University Hospitals Cleveland Medical Center Cleveland OH USA"},{"name":"Case Western Reserve University School of Medicine Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"181","article-title":"Epileptic negative myoclonus","volume":"67","author":"Tassinari C.A.","year":"1995","journal-title":"Adv Neurol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2006.12.001"},{"key":"e_1_2_6_4_1","first-page":"199","article-title":"Pathophysiology of negative myoclonus and asterixis","volume":"67","author":"Shibasaki H.","year":"1995","journal-title":"Adv Neurol"},{"issue":"3","key":"e_1_2_6_5_1","first-page":"595","article-title":"A particular form of muscular inhibition in epilepsy: the related epileptic silent period (R.E.S.P.)","volume":"5","author":"Tassinari C.A.","year":"1968","journal-title":"Proc Aust Assoc Neurol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.6.1078"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.11009"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.6.1534"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-5597(93)90098-A"},{"key":"e_1_2_6_10_1","first-page":"143","article-title":"The spread of myoclonic activity through sensorimotor cortex in cortical reflex myoclonus","volume":"67","author":"Rothwell J.C.","year":"1995","journal-title":"Adv Neurol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh661"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2021.1401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T07:43:14Z","timestamp":1713598994000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2021.1401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1684\/epd.2021.1401"],"URL":"https:\/\/doi.org\/10.1684\/epd.2021.1401","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"2021-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}