{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:58:56Z","timestamp":1765357136610},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":67,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic> The aetiology and pathogenesis of medial temporal lobe epilepsy (MTLE) remain unclear, and effective treatments are lacking. The involvement of a dysregulated competing endogenous RNA (ceRNA) network in MTLE is only partially understood. The purpose of this study was to investigate MTLE regulatory networks composed of messenger RNAs (mRNAs), circular RNAs (circRNAs), long non\u2010coding RNAs (lncRNAs), and microRNAs (miRNAs) through a ceRNA network map.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic> RNA sequencing (RNA\u2010seq) and small RNA\u2010seq were used to detect mRNAs, circRNAs, miRNAs, and lncRNAs differentially expressed between post\u2010operation hippocampal tissues of MTLE patients (<jats:italic>n<\/jats:italic> = 3) and paracancer tissues (<jats:italic>n<\/jats:italic> = 3). We performed bioinformatics analysis to identify differentially expressed RNAs and construct the corresponding ceRNA network. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of differentially expressed RNAs were conducted to explore the biological processes and pathways involved in MTLE.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic> We identified 352 differentially expressed mRNAs, 179 circRNAs, and 42 miRNAs in MTLE. A ceRNA network composed of mRNAs, circRNAs, and miRNAs was constructed. GO and KEGG analysis of the network suggested a key role of synapses and mTOR, cAMP, ErbB, FoxO, and HIF\u20101 signalling pathways in MTLE.<\/jats:p><jats:p><jats:italic>Significance<\/jats:italic> We identify a new circRNA\u2010miRNA\u2010mRNA ceRNA network in MTLE. These results can help clarify the aetiology of MTLE and identify targeted molecular therapies.<\/jats:p>","DOI":"10.1684\/epd.2021.1403","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T06:41:35Z","timestamp":1653115295000},"page":"373-385","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Construction and analysis of a competing endogenous RNA network associated with circRNAs dysregulated in medial temporal lobe epilepsy"],"prefix":"10.1002","volume":"24","author":[{"given":"Kelu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Geriatric Neurology First Affiliated Hospital of Kunming Medical University, Kunming Yunnan Province 650032 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongmin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology Kunming First People's Hospital, Kunming Yunnan 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