{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T22:58:18Z","timestamp":1788044298306,"version":"build-2784847793"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":48,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold><jats:italic>Objective<\/jats:italic><\/jats:bold>. <jats:italic>D\u00e9j\u00e0\u2010vu<\/jats:italic> is a mental phenomenon commonly experienced during temporal lobe seizures and can be evoked by electrical stimulation of the temporal lobe. We analyzed reproducible <jats:italic>d\u00e9j\u00e0\u2010vu<\/jats:italic> experiences evoked by stimulating the insula in two patients with pharmacoresistant temporal lobe epilepsy.<\/jats:p><jats:p><jats:bold><jats:italic>Methods<\/jats:italic><\/jats:bold>. We reviewed video\u2010electroencephalography (EEG) recordings from extraoperative electrical cortical stimulation sessions. In addition, we performed the directed transfer function (DTF) effective connectivity measure of monopolar signals in Patient 1. To highlight elective changes due to each stimulation, we subtracted pre\u2010stimulation DTF matrices from early poststimulation matrices. This analysis was performed for both non\u2010inducing\u2010<jats:italic>d\u00e9j\u00e0vu<\/jats:italic> stimulation (control matrix) and <jats:italic>d\u00e9j\u00e0\u2010vu<\/jats:italic>\u2010inducing stimulation (active matrix). Finally, the control matrix was subtracted from the active matrix.<\/jats:p><jats:p><jats:bold><jats:italic>Results<\/jats:italic><\/jats:bold>. Comparison of effective connectivity during control stimulation versus <jats:italic>d\u00e9j\u00e0\u2010vu<\/jats:italic>\u2010inducing stimulation revealed a reversal of connectivity levels in three main regions: the contralateral inferior insula (the ipsilateral insula could not be analyzed), bilateral mesiotemporal regions and the ipsilateral superior frontal gyrus. The drivers of evoked <jats:italic>d\u00e9j\u00e0\u2010vu<\/jats:italic> were the mesiotemporal regions (mainly ipsilateral) and the ipsilateral superior frontal gyrus.<\/jats:p><jats:p><jats:bold><jats:italic>Significance<\/jats:italic><\/jats:bold>. Although our findings are possibly anecdotal, the insula may (in rare instances) remotely generate unexpected <jats:italic>d\u00e9j\u00e0\u2010vu<\/jats:italic>. If confirmed by further studies, this might change the assessment strategy for possible causes of anterior temporal lobectomy failure.<\/jats:p>","DOI":"10.1684\/epd.2022.1433","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T10:17:43Z","timestamp":1656584263000},"page":"561-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>D\u00e9j\u00e0\u2010vu<\/i> evoked by electrical stimulation of the insula"],"prefix":"10.1002","volume":"24","author":[{"given":"D\u00e8nahin Hinnoutondji","family":"Toffa","sequence":"first","affiliation":[{"name":"Department of Neurosciences Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Bou Assi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"P\u00e9pin","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Martineau","sequence":"additional","affiliation":[{"name":"Division of Neurology Centre Hospitalier de l'Universit\u00e9 Laval Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Robert","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Bouthillier","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dang Khoa","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal Canada"},{"name":"Division of Neurology Centre Hospitalized de l'Universit\u00e9 de Montr\u00e9al Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.04.018"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2012.03.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410120203"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2010.04.009"},{"key":"e_1_2_7_6_1","first-page":"539567","article-title":"Deja experiences in temporal lobe epilepsy","volume":"2012","author":"Illman NA","year":"2012","journal-title":"Epilepsy Res Treat"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/11.2.179"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.1.71"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/101.1.83"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000137037.56916.3F"},{"issue":"1","key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/brain\/awl329","article-title":"The dreamy state: hallucinations of autobiographic memory evoked by temporal lobe stimulations and seizures","volume":"130","author":"Vignal J\u2010P","year":"2007","journal-title":"Brain"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.08.012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02329.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","unstructured":"OmidvarniaAH MesbahM O'TooleJM ColditzPB BoashashB. Analysis of the time\u2010varying cortical neural connectivity in the newborn EEG: a time\u2010frequency approach. In:International Workshop on Systems Signal Processing and Their Applications. WOSSPA (Tipaza).2011:179\u201382.","DOI":"10.1109\/WOSSPA.2011.5931445"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02755.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1200143109"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000382"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0296-3"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.212"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26995-0"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2022.1433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T07:38:09Z","timestamp":1713598689000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2022.1433"}},"subtitle":["Stimulation\u2010induced insular <i>d\u00e9j\u00e0\u2010vu<\/i>"],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1684\/epd.2022.1433"],"URL":"https:\/\/doi.org\/10.1684\/epd.2022.1433","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"2020-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}