{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:17:07Z","timestamp":1768274227243,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anti\u2010seizure medications (ASMs) can cause non\u2010convulsive status epilepticus (NCSE), but account for less than 5% of all NCSE cases. We present a 63\u2010year\u2010old, right\u2010handed male with a history of intractable focal epilepsy since age seven years old, whose bouts of NCSE were triggered by cannabidiol (CBD) adjunctive therapy. His most common seizure types included focal myoclonic or tonic seizures with vocalization, usually with awakening, which occurred on a monthly basis despite the combination of tiagabine, perampanel, levetiracetam, lacosamide and clonazepam. After CBD was initiated, he began to exhibit episodes of prolonged confusion, at times with myoclonic or tonic seizures. Increasing CBD doses led to more frequent and prolonged episodes. The confusional episodes occurred predominantly in the morning, with spontaneous resolution by the afternoon. During one of these episodes, he was hospitalized, and NCSE was confirmed by video\u2010EEG monitoring. CBD was withdrawn and the patient had no further episodes of NCSE. While CBD can cause NCSE, the medication interaction between CBD and tiagabine also needs to be considered.<\/jats:p>","DOI":"10.1684\/epd.2022.1435","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T06:38:51Z","timestamp":1655447931000},"page":"713-718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Non\u2010convulsive status epilepticus in the setting of cannabidiol adjunctive therapy"],"prefix":"10.1002","volume":"24","author":[{"given":"Asra","family":"Tanwir","sequence":"first","affiliation":[{"name":"Department of Neurology University of Texas Health San Antonio San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. \u00c1kos","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Texas Health San Antonio San Antonio Texas USA"},{"name":"Department of South Texas Comprehensive Epilepsy Center University of Texas Health San Antonio San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13121"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2015.04.034"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb00835.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00258.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1081\/CLT-120002889"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12631"},{"issue":"3","key":"e_1_2_6_8_1","first-page":"285","article-title":"Add\u2010on cannabidiol treatment for drugresistant seizures in Tuberous Sclerosis Complex: a placebo\u2010controlled randomized clinical trial","volume":"78","author":"Thiele EA","year":"2021","journal-title":"JAMA"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X17666190603171901"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00379-8"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14477"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.01600.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/seiz.2001.0594"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2004.03.027"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199855030-00013"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8070989"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2022.1435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T07:36:00Z","timestamp":1713598560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2022.1435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1684\/epd.2022.1435"],"URL":"https:\/\/doi.org\/10.1684\/epd.2022.1435","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"2017-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}