{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:16:50Z","timestamp":1767665810122},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010270","name":"Capital Health Research and Development of Special Fund","doi-asserted-by":"publisher","award":["2016\u20101\u20102011","2020\u20101\u20102013"],"award-info":[{"award-number":["2016\u20101\u20102011","2020\u20101\u20102013"]}],"id":[{"id":"10.13039\/501100010270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["Z200024"],"award-info":[{"award-number":["Z200024"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold><jats:italic>Objective<\/jats:italic><\/jats:bold>. We explored changes in heart rate during the peri\u2010ictal period in patients with focal epilepsy, and differences in heart rate changes according to epileptic site and side were assessed.<\/jats:p><jats:p><jats:bold><jats:italic>Methods<\/jats:italic><\/jats:bold>. A total of 198 epileptic seizures in 102 patients with focal epilepsy, who had a definite epileptogenic focus and had undergone surgical treatment, were assessed from 2014 to 2019. Heart rate was measured manually during the peri\u2010ictal period. Change in heart rate and the time it occurred were assessed and compared between different epileptic sites and sides.<\/jats:p><jats:p><jats:bold><jats:italic>Results<\/jats:italic><\/jats:bold>. Heart rate increased in 177 (89.4%) of 198 seizures. In 82 (44.8%) of 183 seizures, the change in heart rate occurred before seizure onset. The median period of heart rate change was seven seconds (interquartile range: 3\u201311 seconds) in seizures with heart rate change before seizure onset. The number of seizures with heart rate increase before seizure onset was significantly greater for medial temporal lobe epilepsy compared to lateral temporal lobe epilepsy (<jats:italic>p<\/jats:italic>=0.019) and extratemporal lobe epilepsy (<jats:italic>p<\/jats:italic>=0.002).<\/jats:p><jats:p><jats:bold><jats:italic>Significance<\/jats:italic><\/jats:bold>. A change in heart rate prior to seizure onset is more likely to occur in patients with medial temporal lobe epilepsy, compared to those with lateral temporal lobe epilepsy and extratemporal lobe epilepsy. Patients with medial temporal lobe epilepsy may likely benefit from seizure warning and detection devices.<\/jats:p>","DOI":"10.1684\/epd.2022.1473","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T09:00:30Z","timestamp":1659085230000},"page":"906-916","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Changes in heart rate during the peri\u2010ictal period in focal epilepsy"],"prefix":"10.1002","volume":"24","author":[{"given":"Jiankui","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital, Capital Medical University  Beijing 100070 China"},{"name":"Department of Neurology Anyang District Hospital of Henan Province  Anyang 455000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guifeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Anyang District Hospital of Henan Province  Anyang 455000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baohua","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Neurology Anyang District Hospital of Henan Province  Anyang 455000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxing","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Neurology Anyang District Hospital of Henan Province  Anyang 455000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhong","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology Anyang District Hospital of Henan Province  Anyang 455000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqiu","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital, Capital Medical University  Beijing 100070 China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing 100070 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Radiology Baoding Second People\u2019s Hospital  Baoding 071051 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital, Capital Medical University  Beijing 100070 China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing 100070 China"},{"name":"Beijing Institute of Brain Disorders Collaborative Innovation Center for Brain Disorders, Capital Medical University  Beijing 100069 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