{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:03:52Z","timestamp":1769504632772,"version":"3.49.0"},"reference-count":0,"publisher":"Il Pensiero Scientifico Editore","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:p>Summary. Plasma cell multiple myeloma (MM) is a multiform clinical entity characterized by different laboratory hallmarks. This case shows a rare entity of plasma cell myeloma: the entire plasma cell population lack the CD138 expression. In this case, a careful analysis of laboratory finding, particular flow cytometry gating strategies and the use of other ancillary laboratory tests, guide the clinicians to correct diagnosis. The correct evaluation of pre-analytical phase and the correct gating strategy are the necessary conditions to produce robust and solid flow cytometric results. The diagnostic implications of CD138-negative plasma cell are strictly linked to stem cell-like clonogenic features, such as possible more aggressive clinical behaviour and increasing probability of chemotherapy resistance. At this time, clinical laboratory remains the main reference point to MM diagnosis.<\/jats:p>","DOI":"10.1701\/4262.42403","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T22:21:36Z","timestamp":1769466096000},"source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis of rare entity CD138 negative plasma cell multiple myeloma: the synergy between laboratory and clinician makes the difference"],"prefix":"10.1701","volume":"115","author":[{"given":"Roberto","family":"Assandri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Inzoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Manini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Fasoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Grassini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"55112","container-title":["Recenti Progressi in Medicina"],"original-title":[],"deposited":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T22:21:37Z","timestamp":1769466097000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.recentiprogressi.it\/articoli.php?archivio=yes&vol_id=4262&id=42403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5,1]]}},"URL":"https:\/\/doi.org\/10.1701\/4262.42403","relation":{},"ISSN":["0034-1193"],"issn-type":[{"value":"0034-1193","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,1]]}}}