{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:09:47Z","timestamp":1769605787114,"version":"3.49.0"},"reference-count":25,"publisher":"CSIRO Publishing","issue":"3","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":1532,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Medicine reviews are an opportunity to identify and address inappropriate prescribing. The aim of this study was to explore changes in benzodiazepine use among older Australians following a medicine review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study type:<\/jats:title>\n                    <jats:p>Retrospective observational cohort study using linked administrative data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We used Medicare Benefits Schedule and Pharmaceutical Benefits Scheme claims from a random 10% sample of Medicare beneficiaries. We identified people aged 65 years or older who received a medicine review in 2013\u201314 and were using benzodiazepines at the time of review. We identified a propensity score matched comparison cohort of those using benzodiazepines who did not receive a review. Two outcome measures were used: any benzodiazepine use and changes to the quantity of benzodiazepines dispensed (diazepam equivalents) from baseline to 90 and 180 days following a medicine review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We identified 4002 people using benzodiazepines on the day of their medicine review, of whom approximately one-third discontinued benzodiazepines within 90 days (29.7%) and 180 days (36.4%) after the review. We observed a similar discontinuation rate in the comparison group (32.6%, p = 0.006; and 38.0%, p = 0.12, respectively). In people who were dispensed lower quantities of benzodiazepines (less than 250 mg of diazepam equivalents in the 90 days before the medicine review), we found that 50.3% ceased using benzodiazepines or used lower quantities (measured as diazepam equivalents) following the medicine review (28.7% and 19.7%, respectively). We also observed a reduction in the quantities used in people where initial exposure was high (3.4% ceased; 59.4% decreased). We observed a similar change in volume within the matched comparison group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Medicine reviews are not associated with any additional reduction in benzodiazepine use among older adults, up to 180 days after review, beyond what was observed in the general population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.17061\/phrp30452015","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T16:46:31Z","timestamp":1608655591000},"source":"Crossref","is-referenced-by-count":2,"title":["Medicine reviews: do they reduce benzodiazepine use in older Australians?"],"prefix":"10.1071","volume":"31","author":[{"given":"Leo","family":"Coleman","sequence":"first","affiliation":[{"name":"A Centre for Big Data Research in Health, UNSW Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Brett","sequence":"additional","affiliation":[{"name":"A Centre for Big Data Research in Health, UNSW Sydney, Australia"},{"name":"B Clinical Pharmacology and Toxicology Department, St Vincent\u2019s Hospital, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Daniels","sequence":"additional","affiliation":[{"name":"A Centre for Big Data Research in Health, UNSW Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sallie","family":"Pearson","sequence":"additional","affiliation":[{"name":"A Centre for Big Data Research in Health, UNSW Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Falster","sequence":"additional","affiliation":[{"name":"A Centre for Big Data Research in Health, UNSW Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"2026012718463195000_R1","doi-asserted-by":"crossref","unstructured":"Castelino RL, Hilmer SN, Bajorek BV, Nishtala P, Chen TF. Drug Burden Index and potentially inappropriate medications in community-dwelling older people: the impact of home medicines review. Drugs aging. 2010;27(2):135\u201348. CrossRef | PubMed","DOI":"10.2165\/11531560-000000000-00000"},{"key":"2026012718463195000_R2","doi-asserted-by":"crossref","unstructured":"Morin L, Laroche ML, Texier G, Johnell K. Prevalence of potentially inappropriate medication use in older adults living in nursing homes: a systematic review. J Am Med Dir Assoc. 2016;17(9):862.e1\u20139. CrossRef | PubMed","DOI":"10.1016\/j.jamda.2016.06.011"},{"key":"2026012718463195000_R3","doi-asserted-by":"crossref","unstructured":"Roughead EE, Anderson B, Gilbert AL. Potentially inappropriate prescribing among Australian veterans and war widows\/widowers. Intern Med J. 2007;37(6):402\u20135. 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