{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T07:21:40Z","timestamp":1772176900300,"version":"3.50.1"},"reference-count":29,"publisher":"Korean Gerontological Nursing Society","issue":"1","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002648","name":"Catholic University of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.jkgn.org"],"crossmark-restriction":true},"short-container-title":["J Korean Gerontol Nurs"],"abstract":"<jats:p>Purpose: This study examined the associations between the types and number of chronic diseases and adverse drug reactions (ADRs) in community-dwelling older adults, aiming to identify high-risk groups and inform nursing strategies for medication safety. Methods: This cross-sectional analysis included 4,478 adults aged \u226565 years from the 2021 Korea Health Panel Survey. Thirty-one physician-diagnosed chronic diseases were grouped into 11 categories, and the number of diseases was classified as 0~1, 2, 3, 4, or \u22655. ADRs were operationally defined using a single self-report item asking whether participants had experienced side effects from any medications, including over-the-counter drugs. Multiple logistic regression analyses adjusted for sociodemographic and health-related covariates were conducted to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: Arthritis and spinal diseases showed the strongest association with ADRs (OR=2.16, 95% CI=1.44~3.24), followed by depression (OR=2.15, 95% CI=1.22~3.79) and cardio-cerebrovascular diseases (OR=1.86, 95% CI=1.25~2.77). ADR risk increased progressively with multimorbidity: OR=1.87 for two diseases, 2.63 for three, 3.15 for four, and 6.22 for \u2265five diseases, compared with 0~1 diseases. Conclusion: ADRs were significantly more likely among older adults with arthritis and spinal diseases, depression, or cardio-cerebrovascular diseases, with risk escalating as multimorbidity increased. Embedding disease type and burden into nursing assessment enables targeted medication review, education, and proactive monitoring. Such nurse-led, collaborative strategies can mitigate drug-related harm and inform policy and training for safe medication use in aging populations.<\/jats:p>","DOI":"10.17079\/jkgn.2025.00374","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:04:02Z","timestamp":1772168642000},"page":"38-48","update-policy":"https:\/\/doi.org\/10.17079\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations between chronic disease profiles and self-reported adverse drug reactions in community-dwelling older adults: A cross-sectional study"],"prefix":"10.17079","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5905-3930","authenticated-orcid":true,"given":"Han-Gyo","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6725","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2021-068208"},{"key":"ref2","volume-title":"Population projections [Internet]","year":"2022"},{"key":"ref3","volume-title":"2023 National survey of older Koreans (Research Report No. 2023-84) [Internet]","author":"Kang","year":"2024"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-018-0795-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_237641"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0252161"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3399\/BJGP.2022.0181"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-56855-z"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S71178"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-055551"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75888-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare13131531"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12102163"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2023.09.012"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s41999-021-00535-y"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-024-05515-y"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1401"},{"key":"ref18","volume-title":"Obesity: preventing and managing the global epidemic: report of a WHO consultation. 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