{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:06:13Z","timestamp":1791835573006,"version":"4.3.4"},"reference-count":0,"publisher":"Il Pensiero Scientifico Editore","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:p>Summary. Background. Borderline personality disorder (BPD) is a complex mental health condition with an altered image of self, impulsive acts, suicidal ideation, and self-harm requiring intensive care in outpatient and inpatient settings. The biopsychosocial (BPS) model adopted in the current study extracted the outcomes of a research about the diagnosis, causes and treatment of BPD. A network model helped link these results in a unitary model with applications in clinical practice for assessment and intervention. Methods. We conducted a literature review of current studies on the BPS causes of BPD and merged them through meta-synthesis. The results were then elaborated with a psychopathological network analysis for linking the extracted factors with higher degree of centrality in the network and merged in a final comprehensive model. Results. The theoretical modelisation suggests that BPS causes merged with the diathesis-stress model persistently activate the cortico-limbic system and prefrontal cortex, induce neuroinflammation, and stimulate suicidal and parasuicidal ideation and behaviours modulated by psychological and pharmacological treatment. Conclusions. Using a network model in psychopathology allowed the merging of data about BPD into a unitary and dynamic pattern which can be helpful to direct assessments and interventions in clinical practice.<\/jats:p>","DOI":"10.1708\/4143.41406","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T22:15:10Z","timestamp":1769465710000},"source":"Crossref","is-referenced-by-count":5,"title":["Biopsychosocial theories of borderline personality disorder: a meta-synthesis and psychopathological network model from a systematic review"],"prefix":"10.1708","volume":"58","author":[{"given":"Carlo","family":"Lazzari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Rabottini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"55112","container-title":["Rivista di Psichiatria"],"original-title":[],"deposited":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T22:15:10Z","timestamp":1769465710000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.rivistadipsichiatria.it\/articoli.php?archivio=yes&vol_id=4143&id=41406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,11,1]]}},"URL":"https:\/\/doi.org\/10.1708\/4143.41406","relation":{"is-cited-by":[{"id-type":"doi","id":"10.4018\/979-8-3693-3338-9.ch002","asserted-by":"object"},{"id-type":"doi","id":"10.31083\/BP42940","asserted-by":"object"}]},"ISSN":["0035-6484"],"issn-type":[{"value":"0035-6484","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11,1]]}}}