{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:50:59Z","timestamp":1791453059894,"version":"4.3.3"},"reference-count":0,"publisher":"Il Pensiero Scientifico Editore","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>Summary. Aim. In Italy, aripiprazole once-monthly 400 mg (AOM 400) can be initiated using a two-injection start (TIS) in adult patients diagnosed with schizophrenia who are stabilised with oral aripiprazole. With this approach, treatment initiation is completed in a single day, without the need for 14 days of concurrent oral aripiprazole supplementation. This study examined how healthcare professionals (HCPs) view and use the AOM 400-TIS in real-world clinical practice in Italy, a country where uptake of the AOM 400-TIS has been relatively high. Methods. Responses were analysed for Italian physicians and nurses who participated in a pan-European, non-interventional, cross-sectional online survey that explored perspectives and attitudes towards prescribing and\/or administering AOM 400-TIS in patients diagnosed with schizophrenia. Responses were collected across two waves and were analysed descriptively. Results. Responses were available for 108 Italian HCPs, representing 47.2% of all survey participants. Common reasons for using the AOM 400-TIS were poor treatment adherence (81.5%), patient preference (50.0%), and disease relapse (42.6%), while common barriers to its use were patient reluctance to receive two injections (36.1%), concerns about tolerability (24.1%), and concerns about safety (23.1%). Most HCPs agreed or strongly agreed that the AOM 400-TIS resulted in satisfactory patient outcomes (85.2%), was easy to administer (82.4%), and had a safety\/tolerability profile similar to the traditional one-injection start (69.4%). Discussion. The results confirm the favourable clinical opinions, perspectives, and experiences of Italian HCPs who prescribe and\/or administer the AOM 400-TIS in clinical practice.<\/jats:p>","DOI":"10.1708\/4785.48115","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:04:25Z","timestamp":1791450265000},"source":"Crossref","is-referenced-by-count":0,"title":["Initiation of aripiprazole once-monthly using a two-injection start in adult patients diagnosed with schizophrenia: real-world views and experiences of Italian healthcare professionals"],"prefix":"10.1708","volume":"61","author":[{"given":"Murat","family":"Yildirim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clodagh","family":"Beckham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Pappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Leopold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Cottam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Hickey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Rogerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Fagiolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"55112","container-title":["Rivista di Psichiatria"],"original-title":[],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:04:26Z","timestamp":1791450266000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.rivistadipsichiatria.it\/articoli.php?archivio=yes&vol_id=4785&id=48115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1708\/4785.48115","relation":{},"ISSN":["0035-6484"],"issn-type":[{"value":"0035-6484","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,1]]}}}