{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:00:32Z","timestamp":1740175232167,"version":"3.37.3"},"reference-count":24,"publisher":"The Korean Society of Anesthesiologists","issue":"4","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anesth-pain-med.org"],"crossmark-restriction":true},"short-container-title":["Anesth Pain Med"],"published-print":{"date-parts":[[2020,10,30]]},"abstract":"<jats:p>Background: Lightwand is a convenient tool that can be used instead of a laryngoscope for intubation. Tracheal intubation causes direct stimulation of the larynx, drastically increasing hemodynamic values including blood pressure and heart rate. This study aims to identify the effect of different doses of esmolol on hemodynamic changes during lightwand intubation.Methods: The study subjects included 140 patients who underwent general anesthesia for elective surgery. The patients were randomly divided into four groups (35 patients in each group). The \u2018C\u2019 group only received 20 ml of normal saline, while the \u2018E0.5\u2019, \u2018E1\u2019, and \u2018E2\u2019 groups received 20 ml of normal saline containing esmolol\u20140.5 mg\/kg, 1 mg\/kg, and 2 mg\/kg, respectively, injected 2 min prior to intubation. The patients\u2019 blood pressure, heart rate, and rate-pressure product were measured six times, before and after the intubation.Results: The degree of heart rate elevation was suppressed in the E1 and E2 groups compared to the C group, and RPP after intubation significantly decreased in the E2 group compared to the C group.Conclusions: 1\u20132 mg\/kg of a single esmolol injection prior to lightwand intubation effectively blunts heart rate elevation, and 2 mg\/kg of esmolol injection blunts rate-pressure product elevation.<\/jats:p>","DOI":"10.17085\/apm.19067","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T02:28:33Z","timestamp":1604024913000},"page":"417-423","update-policy":"https:\/\/doi.org\/10.17085\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dosing study of esmolol for reducing hemodynamic changes during lightwand 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