{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:32:58Z","timestamp":1784140378048,"version":"3.55.0"},"reference-count":23,"publisher":"The Korean Society of Anesthesiologists","issue":"4","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI18C2383"],"award-info":[{"award-number":["HI18C2383"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["anesth-pain-med.org"],"crossmark-restriction":true},"short-container-title":["Anesth Pain Med"],"published-print":{"date-parts":[[2022,10,31]]},"abstract":"<jats:p>Background: Patients with acute-on-chronic liver failure (ACLF) are critically ill and have high waiting-list mortality. Although studies demonstrated that appropriately treated coronary artery disease (CAD) should not be regarded as a contraindication to liver transplant (LT), data regarding long-term outcomes in critically ill liver LT recipients are lacking. The aim of this study was to compare the rates of all-cause death at 5 years following LT in patients with ACLF with or without CAD.Methods: Between 2010 and 2020, we evaluated 921 consecutive LT patients (MELD score, 32 \u00b1 9) and ACLF classified by CLIF-C ACLF score. Up to 5-year all-cause death according to the CAD status was examined. CAD was defined as a preoperative history of coronary artery bypass graft or a percutaneous intervention and old myocardial infarction. Kaplan-Meier survival analysis was used.Results: Up to 5 years, 212 (23.0%) of all ACLF patients (n = 921) in whom 17 (29.3%) of 58 CAD patients died. In patients with CAD (6.3%, 58\/921), the Kaplan-Meier cumulative mortality rate at 5 years was numerically higher but was not statistically significant when compared with those without CAD (32.9% vs. 23.5%, log-rank, P = 0.25). In subgr oup analysis, there were comparable risks of cumulative mortalities at 5 years across the stratification of ACLF grade 1, 2, and 3 (log-rank P = 0.062, P = 0.72, and P = 0.999, respectively).Conclusions: All-cause mortality is high in patients with ACLF after LT but is not related to the presence of revascularized or treated CAD, across the stratification of ACLF grades.<\/jats:p>","DOI":"10.17085\/apm.22168","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T07:18:18Z","timestamp":1666768698000},"page":"412-419","update-policy":"https:\/\/doi.org\/10.17085\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Five-year all-cause mortality in critically ill liver transplant patients with coronary artery disease: analysis of acute-on chronic liver failure"],"prefix":"10.17085","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7788-9555","authenticated-orcid":true,"given":"Hye-Mee","family":"Kwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0041-3054","authenticated-orcid":true,"given":"Jae Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7355-507X","authenticated-orcid":true,"given":"Ji-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3627-1107","authenticated-orcid":true,"given":"Gyu-Sam","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2573","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcaa009"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2018.71.2.85"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31661"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30913"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2459\/jcm.0000000000000207"},{"key":"ref6","first-page":"793","volume-title":"Outcome of liver transplant recipients with revascularized coronary artery disease: a comparative analysis with and without cardiovascular risk factors","author":"Satapathy","year":"2017"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14092"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.042"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15852"},{"key":"ref10","first-page":"1038","volume-title":"CANONIC study investigators of the EASL-CLIF Consortium. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure","author":"Jalan","year":"2014"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.06.026"},{"key":"ref12","first-page":"466","volume-title":"","author":"Moon","year":"2015"},{"key":"ref13","volume-title":"autoReg: automatic linear and logistic regression and survival analysis. Web-R.org [Internet]","author":"Moon"},{"key":"ref14","volume-title":"A package for survival analysis in S. Version 2.38. CRAN.R-project.org [Internet]","author":"Therneau"},{"key":"ref15","volume-title":"A package for survival analysis in R. R package version 3.4-0. CRAN.R-project.org [Internet]","author":"Therneau"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.41"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.045"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i46.5203"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.10.013"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31647"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2459\/jcm.0000000000000207"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15263"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0b013e31823eb07a"}],"container-title":["Anesthesia and Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/anesth-pain-med.org\/upload\/pdf\/apm-22168.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/anesth-pain-med.org\/journal\/view.php?doi=10.17085\/apm.22168","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/anesth-pain-med.org\/upload\/pdf\/apm-22168.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T02:07:00Z","timestamp":1667182020000},"score":1,"resource":{"primary":{"URL":"http:\/\/anesth-pain-med.org\/journal\/view.php?doi=10.17085\/apm.22168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,31]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10]]}},"URL":"https:\/\/doi.org\/10.17085\/apm.22168","relation":{},"ISSN":["1975-5171","2383-7977"],"issn-type":[{"value":"1975-5171","type":"print"},{"value":"2383-7977","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,31]]},"assertion":[{"value":"2022-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-26","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-31","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}