{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:22:23Z","timestamp":1787023343779,"version":"build-2736575974"},"reference-count":0,"publisher":"Faculty of Food Technology and Biotechnology - University of Zagreb","issue":"3","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/www.ftb.com.hr\/info-for-authors\/copyright-and-archiving"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2012BAD12B07"],"award-info":[{"award-number":["2012BAD12B07"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Food Technol. Biotechnol. (Online)"],"published-print":{"date-parts":[[2020,10,31]]},"abstract":"<jats:p>SUMMARY\nResearch background. Depression has become a global threat to human health. In order to solve it, researchers have conducted multi-faceted studies including diet. Many food-derived bioactive substances have shown antidepressant effects. However, there are few studies on the design of industrialized food with antidepressant effect. This study aimed to evaluate the antidepressant effect of a functional beverage made from several ingredients with potential antidepressant function and investigate its antidepressant mechanisms.\nExperimental approach. The beverage consists of peppermint oil, active peptides derived from bovine milk casein and Acanthopanax senticosus extract (ASE) whose active ingredient is eleutheroside. Different amounts of ASE were evaluated to determine the optimal concentration of eleutheroside in this functional beverage to deliver best antidepressant effect through extensive behavioral testing including preliminary acute stress experiments and further chronic unpredictable mild stress test.\nResults and conclusions. The results demonstrated that the beverage with 15.00 mg\/kg of eleutheroside could significantly reduce the mice\u2019s immobility time of tail suspension test and forced swimming test, recover mice\u2019s sucrose preference and behavior changes in the open-field test, improve the contents of dopamine, norepinephrine, 5-hydroxytryptamine and the activity of superoxide dismutase and reduce the content of malondialdehyde in mice\u2019s brains, which indicated that the improvement of monoamine neurotransmitter systems and antioxidation was one potential mechanism of antidepressant action.\nNovelty and scientific contribution. This study provides a design of antidepressant functional beverage and an efficient way for the prevention and treatment of depression.<\/jats:p>","DOI":"10.17113\/ftb.58.03.20.6568","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T05:00:11Z","timestamp":1599454811000},"page":"295-302","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of the Antidepressant Effect of the Functional Beverage Containing Active Peptides, Menthol and Eleutherosides, and Investigation of Its Mechanism of Action in Mice"],"prefix":"10.17113","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1017-6494","authenticated-orcid":false,"given":"Yuanjin","family":"Qi","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, 712100 Yangling, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0113-2657","authenticated-orcid":false,"given":"Huizhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, 712100 Yangling, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1433-6600","authenticated-orcid":false,"given":"Sha","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, 712100 Yangling, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2068-509X","authenticated-orcid":false,"given":"Jiajia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Food Science, University of Tennessee, 2510 River Dr, TN 37996 Knoxville, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3517-7343","authenticated-orcid":false,"given":"Xiaoni","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, 712100 Yangling, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5397-4712","authenticated-orcid":false,"given":"Zhouyu","family":"Duan","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, 712100 Yangling, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2640-9202","authenticated-orcid":false,"given":"Deyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, 712100 Yangling, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4833-001X","authenticated-orcid":false,"given":"Zhicheng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, 712100 Yangling, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6678","published-online":{"date-parts":[[2020,9,7]]},"container-title":["Food Technology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ftb.com.hr\/images\/pdfarticles\/2020\/July-September\/FTB-58-295.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T05:37:28Z","timestamp":1604295448000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ftb.com.hr\/current-issue\/181-volume-58-issue-no-3\/1676-evaluation-of-the-antidepressant-effect-of-the-functional-beverage-containing-active-peptides-menthol-and-eleutheroside-and-investigation-of-its-mechanism-of-action-in-mice"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,7]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,9,30]]}},"URL":"https:\/\/doi.org\/10.17113\/ftb.58.03.20.6568","relation":{},"ISSN":["1334-2606","1330-9862"],"issn-type":[{"value":"1334-2606","type":"electronic"},{"value":"1330-9862","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9,7]]}}}