{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:01:17Z","timestamp":1785416477755,"version":"3.56.0"},"reference-count":43,"publisher":"Faculty of Food Technology and Biotechnology - University of Zagreb","issue":"4","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.ftb.com.hr\/info-for-authors\/oa-copyright-and-archiving"}],"funder":[{"award":["31270060"],"award-info":[{"award-number":["31270060"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Domestic visiting programs for outstanding young talents in universities China","award":["JY0002221-2022"],"award-info":[{"award-number":["JY0002221-2022"]}]},{"name":"Microbial experimental technique","award":["JY000188-tzpy032"],"award-info":[{"award-number":["JY000188-tzpy032"]}]},{"name":"Major Natural Science Research Project of colleges and universities of Anhui Province","award":["2024AH040182"],"award-info":[{"award-number":["2024AH040182"]}]},{"name":"Major Natural Science Research Project of colleges and universities of Anhui Province","award":["KJ2021zd0164"],"award-info":[{"award-number":["KJ2021zd0164"]}]},{"name":"Modern agricultural industry practice centers on integrated production and instruction","award":["2023cj2x011"],"award-info":[{"award-number":["2023cj2x011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Food Technol. Biotechnol."],"published-print":{"date-parts":[[2025,12,23]]},"abstract":"<jats:p>esearch background. Global food security faces increasing threats from chemical contaminants, with N-nitrosodiethylamine (NDEA) emerging as a potent hepatotoxicant of significant concern. NDEA-induced hepatic injury causes a pathological triad: (i) reactive oxygen species-mediated oxidative cascades, (ii) nuclear factor \u03baB-driven inflammatory amplification, and (iii) gut microbiota-derived endotoxin translocation. Although natural polyphenols have established protective efficacy, fungus-derived variants remain pharmacologically enigmatic, particularly regarding their pathway-specific regulation and microbiota modulation. We comprehensively investigated the therapeutic capacity of Lachnum polyphenols for hepatoprotection.\n\tExperimental approach. The hepatoprotective and microbiota-modulating efficacy of extracellular polyphenols from Lachnum YM156 (LSP156) was evaluated in an NDEA-induced mouse model. Sixty male Institute of Cancer Research (ICR) mice were randomised into six experimental groups receiving 28-day oral LSP156 treatment. Body mass measurements, hepatosomatic indices, systemic oxidative stress biomarkers (superoxide dismutase [SOD] and malondialdehyde) and proinflammatory cytokines (interleukin [IL]-6 and tumour necrosis factor [TNF]-\u03b1) were assessed. Hepatic histopathology was analysed by haemotoxylin and eosin staining, whereas immunoblotting with chemiluminescence detection assessed the STAT3\/COX-2 pathway activation. Gut microbiota composition was profiled through 16S rRNA sequencing.\n\tResults and conclusions. After 28-day oral administration (50\u2013100 (mg\/kg)\/day), LSP156 significantly improved somatic growth parameters (body mass gain) and organ indices in NDEA-induced mice. LSP156 increased the activities of SOD and catalase, as well as glutathione levels, and greatly reduced the liver function markers alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and total bilirubin. It also improved liver cell damage in tissue samples compared to model controls. LSP156 halted the activation of STAT3 and reduced TLR4 levels, which lowered cyclooxygenase protein levels and protected the liver from damage. LSP156 enhanced the digestion and absorption of carbohydrates and proteins, as well as the biosynthesis of terpenoids such as ubiquinone in mice, by rectifying intestinal flora imbalances, modifying the flora structure and demonstrating a strong correlation between Bacteroidales and Lactobacillales with the reduction of TNF-\u03b1 and IL-6. The LSP156 demonstrated dose-dependent therapeutic efficacy in attenuating oxidative stress, hepatocyte impairment and systemic inflammation.\n\tNovelty and scientific contribution. Fungal polyphenol LSP156 maintains balanced gut bacteria by simultaneously managing inflammation and oxidation. These findings suggest a new approach to designing drugs that target multiple factors in complex metabolic disorders.<\/jats:p>","DOI":"10.17113\/ftb.63.04.25.8809","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T12:23:35Z","timestamp":1759321415000},"page":"470","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Lachnum YM156 Polyphenol on STAT3\/COX-2 Signal Pathway and Gut Microbiota in Mice with N-Nitrosodiethylamine-Induced Hepatic Injury"],"prefix":"10.17113","volume":"63","author":[{"given":"Tingting","family":"Chen","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02czkny70","id-type":"ROR","asserted-by":"publisher"}],"name":"Hefei University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-3196","authenticated-orcid":false,"given":"Dong","family":"Liu","sequence":"additional","affiliation":[{"name":"Anhui Zhanshi Food Corporation, No. 6, South Outer Ring Road, Ningguo City, Postal Code: 242300, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0730-3528","authenticated-orcid":false,"given":"Ming","family":"Ye","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02czkny70","id-type":"ROR","asserted-by":"publisher"}],"name":"Hefei University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6678","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"<jrn>  1. 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